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GlossaryGlucocorticoid Receptor

regulates gene expression by binding to glucocorticoid hormones

The Glucocorticoid Receptor (GR) is a type of protein found inside cells that binds to glucocorticoids, which are a class of steroid hormones. When these hormones bind to the receptor, it can influence the expression of specific genes, thereby regulating processes like inflammation, immune response, and metabolism. This receptor is crucial in medical treatments for conditions like asthma, autoimmune diseases, and even certain types of hair loss, such as alopecia areata.

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research Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance

4 citations, October 2007 in “Dermatologic Clinics”

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

research Glucocorticoid Receptor Antagonism Improves Glucose Metabolism in a Mouse Model of Polycystic Ovary Syndrome

December 2023 in “Journal of the Endocrine Society”

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy

research Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy

23 citations, July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

research Non-Canonical Dimerization of the Androgen Receptor and Other Nuclear Receptors: Implications for Human Disease

25 citations, June 2019 in “Endocrine Related Cancer”

Mutations in certain receptors can cause diseases and offer new treatment options.

research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones

197 citations, January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 41 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community NootBro Recommendations… How Do We Feel

in Research/Science 10 upvotes 10 months ago

The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.

community We Need A Solution For The Inflammatory Response related To AGA

in Research/Science 16 upvotes 7 months ago

The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

community AA and Hirsutism but T levels are normal

in Female 7 upvotes 4 years ago

27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

community No luck with meds, Check your Cortisol.

in Treatment 33 upvotes 8 months ago

Cortisol from stress can cause hair loss. Controlling cortisol levels improved the effectiveness of finasteride for hair regrowth.