Taming of COVID-19: Potential and Emerging Application of Mesenchymal Stem Cells

March 2021 in “ Cytotechnology ”

Nima Najafi-Ghalehlou, Mehryar Habibi Roudkenar, Habib Zayeni Langerodi, Amaneh Mohammadi Roushandeh

Studysummary This review examines recent findings on COVID-19 pneumonia treatment using mesenchymal stem cells and reports no new clinical results; the authors highlight MSCs' potential due to their immunomodulatory and tissue-regenerative properties. Our plain-language summary of this paper — not a Tressless recommendation.

The document reviewed the potential application of mesenchymal stem cells (MSCs) in treating COVID-19, focusing on their immunomodulatory and regenerative properties. MSCs were considered promising for reducing mortality and morbidity by modulating immune responses, preventing cytokine storms, and aiding tissue repair. Various studies and clinical trials, involving participant numbers ranging from 5 to 200, were conducted across multiple countries to assess the safety and efficacy of MSCs derived from sources like umbilical cords and adipose tissue. Preliminary results indicated that MSC therapy was safe and showed potential in improving oxygenation, reducing inflammation, and enhancing recovery in COVID-19 patients. However, limitations such as small sample sizes and lack of randomization were noted, highlighting the need for further research to confirm these findings and establish standardized treatment protocols.

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research Efficacy Assessment of Mesenchymal Stem Cell Transplantation for Burn Wounds in Animals: A Systematic Review

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research Impact of Different Preparation Methods to Obtain Human Adipose-Derived Stromal Vascular Fraction Cells and Human Adipose-Derived Mesenchymal Stem Cells: Enzymatic Digestion Versus Mechanical Centrifugation

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research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations , July 2019 in “International Journal of Molecular Sciences”

In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.

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research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

69 citations , April 2019 in “Biomedicines”

This study found that hair thickness and density increased after treatment with human follicle mesenchymal stem cells and platelet rich plasma, associated with enhanced Wnt signaling and platelet derived growth factors.

Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

research Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

86 citations , June 2017 in “Stem cell investigation”

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