Efficacy Assessment of Mesenchymal Stem Cell Transplantation for Burn Wounds in Animals: A Systematic Review

This systematic review assessed the efficacy of mesenchymal stem cell (MSC) transplantation for burn wound healing in animal models. The analysis included 20 studies and found that stem cell therapy significantly improved the closure rate and reduced the wound area, although the reduction in the un-healing rate was not significant. Additionally, vascular density and eschar tissue thickness were notably enhanced in treated animals, and there was an increase in white blood cell count 5 days post-treatment. However, other factors like VEGF, CD-31, and IL-10 were not significantly affected. The findings suggested that MSC therapy could be beneficial in reducing burn wound areas, providing a basis for future clinical studies.