Editorial: Mesenchymal Stromal Cell Therapy for Regenerative Medicine

The editorial highlights the potential of mesenchymal stromal/stem cell (MSC) therapies in regenerative medicine, emphasizing their ability to modulate immune responses, reduce inflammation, and promote tissue repair. MSCs are versatile, sourced from various origins, and can be expanded and stored for clinical use, making them applicable to diverse diseases, including musculoskeletal, neurological, cardiovascular conditions, cancer, and COVID-19 complications. The document reviews 37 manuscripts on MSC applications, mechanisms, and strategies to enhance efficacy, such as preconditioning and genetic modifications. MSC-derived extracellular vesicles (EVs) are also noted for their therapeutic potential. The editorial underscores the need for standardized clinical trials to improve MSC therapy outcomes, indicating that while MSCs and their derivatives hold promise for advancing regenerative therapies, further research and standardization are necessary.