Current Status of the Applications of Conditioned Media Derived from Mesenchymal Stem Cells for Regenerative Medicine

    January 2023 in “ Physiological Research ”
    Veronika Smolinská, Martin Boháč, Ľuboš Danišovič
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    TLDR Conditioned media from mesenchymal stem cells show promise for tissue repair and disease treatment, but more research is needed on their safety and effectiveness.
    The document reviews the potential of conditioned media (CM) from mesenchymal stem cells (MSCs) in regenerative medicine, emphasizing its role in tissue repair, immunomodulation, and angiogenesis. It suggests that the therapeutic benefits of MSCs may be attributed to their secreted substances rather than cell engraftment. The review covers 10 studies, including 6 pre-clinical and 4 clinical, demonstrating the effectiveness of MSC-CM in various conditions such as bronchopulmonary dysplasia, bone lesions, diabetic polyneuropathy, non-alcoholic fatty liver disease, and its potential in anti-aging and cancer treatment. Clinical trials have shown promising results in treating COPD, SLE, and androgenetic alopecia, with MSC-CM improving pulmonary function, reducing autoimmunity, and enhancing hair growth, respectively. However, the document calls for more research to confirm the safety and efficacy of MSC-CM in humans and addresses challenges in production, storage, and quality control.
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