Current Status of the Applications of Conditioned Media Derived from Mesenchymal Stem Cells for Regenerative Medicine

    January 2023 in “ Physiological Research ”
    Veronika Smolinská, Martin Boháč, Ľuboš Danišovič
    Image of study
    TLDR Conditioned media from mesenchymal stem cells show promise for tissue repair and disease treatment, but more research is needed on their safety and effectiveness.
    The document reviews the potential of conditioned media (CM) from mesenchymal stem cells (MSCs) in regenerative medicine, emphasizing its role in tissue repair, immunomodulation, and angiogenesis. It suggests that the therapeutic benefits of MSCs may be attributed to their secreted substances rather than cell engraftment. The review covers 10 studies, including 6 pre-clinical and 4 clinical, demonstrating the effectiveness of MSC-CM in various conditions such as bronchopulmonary dysplasia, bone lesions, diabetic polyneuropathy, non-alcoholic fatty liver disease, and its potential in anti-aging and cancer treatment. Clinical trials have shown promising results in treating COPD, SLE, and androgenetic alopecia, with MSC-CM improving pulmonary function, reducing autoimmunity, and enhancing hair growth, respectively. However, the document calls for more research to confirm the safety and efficacy of MSC-CM in humans and addresses challenges in production, storage, and quality control.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Lavdik Hair Growth Serum?

      in Product 4 years ago
      A user is concerned about the legitimacy of a hair growth serum called Lavdik, which they ordered after seeing an ad for Jemros. The product contains ginger extract, ginseng extract, fleece flower root, grape seed oil, glycerol, carbomer, propylene glycol, and rosemary oil, and the user is unsure if it is effective or a scam.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

    Similar Research

    5 / 1000+ results