The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring

The study explores the effects of the secretome from irradiated peripheral blood mononuclear cells (PBMCsec) on hypertrophic skin scarring in both mouse and human models. PBMCsec was applied topically and via intradermal injections, demonstrating significant anti-fibrotic effects by downregulating genes associated with fibrosis and myofibroblast differentiation. The research showed that PBMCsec inhibits TGFβ signaling, reduces elastin breakdown, and alters the expression of genes related to the extracellular matrix, leading to improved scar quality. These findings suggest that PBMCsec could be a promising therapeutic option for managing hypertrophic scars, although further clinical assessments are needed.