Adipose Mesenchymal Stem Cells Combined with Platelet-Rich Plasma Accelerate Diabetic Wound Healing by Modulating the Notch Pathway

July 2021 in “ Stem Cell Research & Therapy ”

Nesrine Ebrahim, Arigue A. Dessouky, Ola Mostafa, Amira Hassouna, Mohamed Yousef, Yasmin Seleem, Eman Abd El Aziz M. El Gebaly, Mona M. Allam, Ayman Samir Farid, Bayan A. Saffaf, Dina Sabry, Ahmed Nawar, Ahmed A. Shoulah, Ahmed Khalil, Sami Abdalla, Mohamed El‐Sherbiny, Nehal M. Elsherbiny, Rabab F. Salim

adipose-derived mesenchymal stem cells platelet-rich plasma Notch signaling pathway collagen deposition epithelial thickness capillary count angiogenesis epidermal stem cells ADSCs PRP

TLDR Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.

The study explored the impact of combining adipose-derived mesenchymal stem cells (ADSCs) with platelet-rich plasma (PRP) on the healing of diabetic wounds in rats, particularly focusing on the modulation of the Notch signaling pathway. The results demonstrated that this combination therapy significantly improved wound healing, as evidenced by increased collagen deposition, epithelial thickness, capillary count, and the upregulation of genes associated with angiogenesis and epidermal stem cells. The most notable improvements were seen in the group receiving both ADSCs and PRP, which also exhibited significant changes in the expression of Notch pathway-related genes. The study included 7 rats per group, indicating that the combination of ADSCs and PRP could be a promising strategy for enhancing diabetic wound healing through the modulation of the Notch pathway.

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