Systematic Review: The Potential Implications of Different Platelet-Rich Plasma Concentrations in Regenerative Medicine for Tissue Repair

August 2020 in “ International Journal of Molecular Sciences ”

Pietro Gentile, Simone Garcovich

This systematic review, conducted according to PRISMA-P guidelines, analyzed the effects of different platelet-rich plasma (PRP) concentrations on tissue regeneration. Out of 965 initially identified articles, 15 were analyzed, focusing on two groups: the fixed PRP Concentration Group and the fixed PRP Volume Group. The review found that a PRP concentration of 1.0 × 10^6 plt/μL was optimal for tissue repair due to adequate capillary nutrition and growth factor diffusion. It was also noted that maintaining a PRP/media ratio of ≤10% (Vol/Vol) was crucial to prevent cellular starvation and best mimic in vivo conditions.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research Platelet-Rich Plasma and Its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

12 citations , June 2020 in “Dermatology and therapy”

Platelet-Rich Plasma (PRP) can promote new hair growth and increase hair density, but its effectiveness varies depending on the type of hair loss.

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

research Autologous Activated Platelet-Rich Plasma (AA-PRP) and Non-Activated (A-PRP) in Hair Growth: A Retrospective, Blinded, Randomized Evaluation in Androgenetic Alopecia

44 citations , February 2020 in “Expert Opinion on Biological Therapy”

PRP, especially AA-PRP, can help improve hair growth in androgenetic alopecia.

Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

research Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations , January 2020 in “International Journal of Molecular Sciences”

Different methods of preparing Platelet-Rich Plasma (PRP) can affect wound healing and hair regrowth in plastic surgery. Using a kit with specific standards helps isolate PRP that meets quality criteria. Non-Activated PRP and Activated PRP have varying effects depending on the tissue and condition treated. For hair regrowth, Non-Activated PRP increased hair density more than Activated PRP. Both treatments improved various aspects of scalp health.

research The Physician's Guide to Platelet-Rich Plasma in Dermatologic Surgery Part II: Clinical Evidence

24 citations , November 2019 in “Dermatologic Surgery”

Platelet-rich plasma is most effective for hair loss treatment and wound healing in skin surgery, but more research is needed for consistent results.

The Physician's Guide to Platelet-Rich Plasma in Dermatologic Surgery Part I: Definitions, Mechanisms of Action, and Technical Specifications

research The Physician's Guide to Platelet-Rich Plasma in Dermatologic Surgery Part I: Definitions, Mechanisms of Action, and Technical Specifications

16 citations , November 2019 in “Dermatologic Surgery”

Platelet-rich plasma is most effective for hair loss treatment and shows promise for skin healing and rejuvenation, but more standardized research is needed.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations , July 2019 in “International Journal of Molecular Sciences”

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

research The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review

76 citations , December 2018 in “Aesthetic Plastic Surgery”

Platelet-rich plasma may help in skin and hair treatments, and with muscle and joint healing, but more research is needed to fully understand its benefits and limitations.

research Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

January 2018 in “Journal of Visualized Experiments”

PRP injections significantly increased hair count and density with less pain.

research Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

24 citations , January 2018 in “Journal of Visualized Experiments”

PRP injections effectively promote hair growth in androgenetic alopecia patients.

research Alopecia and Platelet-Derived Therapies

23 citations , November 2017 in “Stem cell investigation”

Platelet lysate is more effective than activated autologous platelet-rich plasma or saline in improving hair growth after hair restoration surgery.

Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.