Systematic Review: The Potential Implications of Different Platelet-Rich Plasma Concentrations in Regenerative Medicine for Tissue Repair

August 2020 in “ International Journal of Molecular Sciences ”

Pietro Gentile, Simone Garcovich

platelet-rich plasma PRP tissue regeneration growth factor diffusion

TLDR A PRP concentration of 1.0 × 10^6 plt/μL is best for tissue repair.

The systematic review from 2020 evaluated the effects of different platelet-rich plasma (PRP) concentrations on tissue repair, analyzing 15 studies from an initial 965 articles. It found that a PRP concentration of 1.0 × 10^6 plt/μL was optimal for tissue repair due to adequate capillary nutrition and growth factor diffusion. A PRP/media ratio of ≤10% (Vol/Vol) was ideal to prevent cellular starvation. The review highlighted the lack of standardized PRP preparation methods, which affected result consistency, and emphasized the need for standardized procedures to ensure reliable treatment outcomes. The review also noted that PRP's effectiveness varied by cell type and origin, with Human Mesenchymal Stem Cells being more responsive than fibroblasts.

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