Systematic Review: The Potential Implications of Different Platelet-Rich Plasma Concentrations in Regenerative Medicine for Tissue Repair

August 2020 in “ International Journal of Molecular Sciences ”

Pietro Gentile, Simone Garcovich

platelet-rich plasma PRP tissue regeneration growth factor diffusion

TLDR A PRP concentration of 1.0 × 10^6 plt/μL is best for tissue repair.

This systematic review, conducted according to PRISMA-P guidelines, analyzed the effects of different platelet-rich plasma (PRP) concentrations on tissue regeneration. Out of 965 initially identified articles, 15 were analyzed, focusing on two groups: the fixed PRP Concentration Group and the fixed PRP Volume Group. The review found that a PRP concentration of 1.0 × 10^6 plt/μL was optimal for tissue repair due to adequate capillary nutrition and growth factor diffusion. It was also noted that maintaining a PRP/media ratio of ≤10% (Vol/Vol) was crucial to prevent cellular starvation and best mimic in vivo conditions.

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