The Physician's Guide to Platelet-Rich Plasma in Dermatologic Surgery Part I: Definitions, Mechanisms of Action, and Technical Specifications

    November 2019 in “ Dermatologic Surgery
    Amelia K. Hausauer, Shannon Humphrey
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    TLDR Platelet-rich plasma is most effective for hair loss treatment and shows promise for skin healing and rejuvenation, but more standardized research is needed.
    The review article from November 2019, led by A. K. Hausauer, provided an in-depth analysis of Platelet-rich plasma (PRP) in dermatology, focusing on its role in hair restoration, soft-tissue remodeling, resurfacing, and rejuvenation. The strongest evidence for PRP's effectiveness was found in treating androgenetic alopecia, followed by post-procedure wound healing, scar revision, striae, rejuvenation, and dermal filling. However, the study highlighted the lack of large randomized controlled trials, significant heterogeneity in the variables studied, and non-specific preparatory protocols, which could influence clinical outcomes. The authors suggested future research should use consistent nomenclature, determine ideal solution parameters for each cutaneous indication, establish significant outcome metrics, and follow double-blinded, randomized, controlled methodologies.
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