Platelet-Rich Plasma Versus Tretinoin in Treatment of Striae Distensae: A Comparative Study

    December 2017 in “ Dermatologic Surgery ”
    Hend Gamil, Samia Ibrahim, Howyda Mohamed Ebrahim, Waleed Albalat
    From the encyclopedia
    Platelet-Rich Plasma →

    growth factors taken from your blood and injected into your scalp to stimulate hair

    Tretinoin →

    the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

    collagen →
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    Studysummary This study found that both intralesional PRP and topical tretinoin were effective and safe for treating striae distensae, with PRP being more effective and yielding higher patient satisfaction. Our plain-language summary of this paper — not a Tressless recommendation.
    The study conducted by Gamil, Hend D. MD; Ibrahim, Samia A. MD; Ebrahim, Howyda M. MD; Albalat, Waleed MD in 2018 compared the effectiveness of platelet-rich plasma (PRP) injections and topical tretinoin 0.05% in treating Striae Distensae (SD), a type of dermal scar. The study involved 30 patients (27 females and 3 males) with bilateral SD. Each patient had half of their selected striae treated with PRP injections and the other half with topical tretinoin. The results showed a statistically significant improvement in SD treated with both PRP and topical tretinoin cream, but the improvement was more significant in the SD treated with PRP injections (p = .015). Patient satisfaction also indicated a greater improvement on the PRP-treated side (p = .003). Both treatments were found to be safe and increased collagen and elastic fibers in the dermis, but PRP was more effective and provided a better therapeutic response than tretinoin.
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