Platelet-Rich Plasma in Melasma: A Systematic Review

    October 2021 in “ Dermatologic Surgery ”
    Rashmi Sarkar, Meenakshi Gupta
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    TLDR Platelet-rich plasma (PRP) can significantly improve melasma, a skin pigmentation disorder, but may not add benefits when used with certain other treatments.
    The systematic review analyzed seven studies on the efficacy and safety of platelet-rich plasma (PRP) in treating melasma, a common hyperpigmentation disorder. Most studies showed significant improvement in melasma when using intradermal injections of PRP. Microneedling mediated delivery of PRP also yielded good results. However, one study found no additional benefit of PRP in patients treated with topical tranexamic acid, and another found no benefit of intense pulsed light in patients treated with intradermal PRP. The review concluded that PRP inhibits melanin synthesis through various components acting through several mechanisms, demonstrating a moderate grade of recommendation according to the Oxford Center for Evidence-Based Medicine 2011 standards.
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      community Thoughts on platelet-rich plasma therapy

      in Treatment  3 upvotes 1 year ago
      Platelet-rich plasma (PRP) therapy for hair loss is expensive, painful, and often ineffective, with mixed reviews on its benefits. Alternatives like minoxidil, finasteride, and hair transplants are suggested as more reliable options.

      community Anyone have PRP/Exosome results to share?

      in Treatment  3 upvotes 3 years ago
      Considering alternative treatments to hair loss, such as platelet-rich plasma (PRP) and exosome therapy, instead of using medications like minoxidil, finasteride/dutasteride.

      community Went from almost balding to some this!

      in Progress Pictures  498 upvotes 2 years ago
      A user successfully regrew hair after nearly going bald by using oral finasteride, topical minoxidil, plasma injections, and mesotherapy over 9 months. They plan to try derma rolling and have an alarm set for taking medication, noting increased sexual drive as a side effect.

      community Shedding ALOT of hairs after 2nd session of PRap

      in Is this regrowth? 2 years ago
      After a second session of Platelet-Rich Plasma (PRP) treatment for hair regrowth, the user is experiencing increased shedding of thick and dark hairs and is concerned about whether this is temporary. They are seeking others' experiences with PRP, specifically regarding the duration of shedding and eventual positive outcomes.

      community Finasteride user thinking of going on Minoxidil: custom version vs. generic?

      in Minoxidil  9 upvotes 2 years ago
      A man in his 50s, who has been on Finasteride for 15 years, is considering adding a custom topical Minoxidil blend to his treatment due to recent hairline recession. He questions whether the custom blend is more effective than generic Minoxidil, expresses concerns about shedding and body hair growth, and seeks advice on application timing with styling products and whether to pursue other treatments like PRP or laser.

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