MSCs and Their Exosomes: A Rapidly Evolving Approach in the Context of Cutaneous Wound Therapy

December 2021 in “ Stem Cell Research & Therapy ”

Faroogh Marofi, Kozlitina Iuliia Alexandrovna, Ria Margiana, Mahta Bahramali, Wanich Suksatan, Walid Kamal Abdelbasset, Supat Chupradit, Maryam Nasimi, Marwah Suliman Maashi

Studysummary This review discusses the potential of mesenchymal stem/stromal cells and their exosomes in promoting wound healing and skin regeneration, but reports no new experimental results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discusses the potential of Mesenchymal Stem Cells (MSCs) and their exosomes in accelerating cutaneous wound healing. MSCs inhibit inflammation, stimulate angiogenesis, and facilitate matrix remodeling, contributing to wound healing. They can differentiate into skin-resident cells and secrete paracrine factors. MSC-derived exosomes, containing lipid, proteins, DNA, microRNA, and mRNA, support skin regeneration by modifying macrophage activation, stimulating angiogenesis, and regulating the turnover of the extracellular matrix. However, challenges such as inconsistency in delivery protocols and MSC population diversities limit their widespread use. Further research and large-scale clinical trials are needed to validate these findings.

View this study on stemcellres.biomedcentral.com →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

research AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

17 citations , March 2021 in “Expert Opinion on Biological Therapy”

This review analyzes the impact of different preparation methods for platelet-rich plasma, human follicles stem cells, and adipose-derived stem cells on hair regrowth and wound healing, but reports no new results; the authors emphasize convincing evidence of positive outcomes despite protocol variability.

research Functional Enhancement Strategies for Immunomodulation of Mesenchymal Stem Cells and Their Therapeutic Application

53 citations , September 2020 in “Stem Cell Research & Therapy”

This review discusses strategies to enhance mesenchymal stem cell therapy effectiveness but reports no new clinical results; it highlights the need for improved consistency and efficacy in MSC-based treatments.

research Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

139 citations , May 2020 in “Stem Cell Research & Therapy”

In this study, human bone marrow mesenchymal stem cell-derived exosomes significantly accelerated cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.

research Platelet-Rich Plasma Accelerates Skin Wound Healing by Promoting Re-Epithelialization

169 citations , January 2020 in “Burns & Trauma”

In this study, autologous platelet-rich plasma improved skin wound healing in mice, associated with reduced inflammation and enhanced angiogenesis and re-epithelialization, but the underlying regulatory mechanism requires further investigation.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

69 citations , April 2019 in “Biomedicines”

This study found that hair thickness and density increased after treatment with human follicle mesenchymal stem cells and platelet rich plasma, associated with enhanced Wnt signaling and platelet derived growth factors.

research Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature

53 citations , June 2017 in “Skin appendage disorders”

This review suggests that platelet-rich plasma may be effective in increasing hair density in patients with androgenetic alopecia, but more research is needed to determine the best treatment protocol.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

This study found that platelet-rich plasma injections significantly increased hair count and density in patients with male pattern hair loss without major side effects, suggesting it may be a safe and effective treatment option.

research Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing

908 citations , July 2015 in “British Journal of Dermatology”

This article reviews the cellular and molecular processes of acute and chronic wound healing, emphasizing the need for collaboration between researchers and clinicians to advance therapeutic solutions; it presents no new clinical results.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , November 2014 in “Developmental Cell”

This study identifies a bipotent stem cell in adult hair follicles that self-renews and contributes to dermal sheath and papilla cell populations, potentially aiding hair regrowth after injury, disease, or aging.

research Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing

238 citations , March 2013 in “Development”

This study found that adipocytes play a crucial role in skin wound healing by facilitating fibroblast recruitment and dermal reconstruction during the healing process.

research Adult Bone-Marrow-Derived Mesenchymal Stem Cells Contribute to Wound Healing of Skin Appendages

201 citations , August 2006 in “Cell and Tissue Research”