MSCs and Their Exosomes: A Rapidly Evolving Approach in the Context of Cutaneous Wound Therapy

    December 2021 in “ Stem Cell Research & Therapy ”
    Faroogh Marofi, Kozlitina Iuliia Alexandrovna, Ria Margiana, Mahta Bahramali, Wanich Suksatan, Walid Kamal Abdelbasset, Supat Chupradit, Maryam Nasimi, Marwah Suliman Maashi
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    TLDR MSCs and their exosomes may speed up skin wound healing but need more research for consistent use.
    The document discusses the potential of Mesenchymal Stem Cells (MSCs) and their exosomes in accelerating cutaneous wound healing. MSCs inhibit inflammation, stimulate angiogenesis, and facilitate matrix remodeling, contributing to wound healing. They can differentiate into skin-resident cells and secrete paracrine factors. MSC-derived exosomes, containing lipid, proteins, DNA, microRNA, and mRNA, support skin regeneration by modifying macrophage activation, stimulating angiogenesis, and regulating the turnover of the extracellular matrix. However, challenges such as inconsistency in delivery protocols and MSC population diversities limit their widespread use. Further research and large-scale clinical trials are needed to validate these findings.
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