TLDR Stem cell treatments may improve burn wound healing.
This systematic review examined 33 preclinical studies on stem cell-based tissue engineering for burn wound treatment, primarily using murine models and occasionally porcine models. The studies, published between 2009 and 2021, mostly involved thermal burns and applied stem cell treatments immediately after injury, with evaluation periods ranging from 7 to 90 days. Mesenchymal stromal cells (MSCs) were the most frequently used stem cell type, sourced from adipose tissue, bone marrow, or umbilical cord, often combined with various biomaterial scaffolds. The findings indicated that stem cell-based treatments showed promising results in enhancing skin wound repair in animal models, suggesting potential as an improved therapy for burn wounds.
24 citations
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August 2021 in “Biologics” Stem cell therapy shows promise in improving burn wound healing.
31 citations
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January 2021 in “Experimental Dermatology” Skin organoids are a promising new model for studying human skin development and testing treatments.
71 citations
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February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
3 citations
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January 2020 in “PubMed” Adding insulin-like growth factor 1 and bone marrow-derived stem cells to a collagen-chitosan scaffold helps wounds heal faster and regrows hair follicles.
169 citations
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January 2018 in “Cell Reports” Scientists grew hair follicles from mouse stem cells in a lab setting.
68 citations
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August 2014 in “Stem Cells Translational Medicine” Dermal papilla cells help wounds heal better and can potentially grow new hair.
162 citations
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July 2011 in “Biomacromolecules” Chitosan nanofiber scaffolds improve skin healing and are promising for wound treatment.
218 citations
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April 2008 in “Genes & Development” Skin stem cells help repair damage and maintain healthy skin.
41 citations
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January 2015 in “Burns & Trauma” Tissue engineering improves burn scar reconstruction by using skin substitutes and replacing damaged tissues.
148 citations
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August 2022 in “Stem Cell Research & Therapy” Encapsulated stem cell exosomes in hydrogel improve wound healing.
20 citations
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June 2020 in “Stem Cell Research & Therapy” Using stem cells from fat tissue can significantly improve wound healing in dogs.
November 2023 in “Linköping University medical dissertations” Keratinocytes and adipose-derived stem cells can effectively heal difficult skin wounds.
72 citations
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January 2023 in “International Journal of Biological Sciences” Engineered exosomes show promise for improving wound healing but face challenges in clinical use.
