Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies

February 2022 in “ Stem Cell Reviews and Reports ”

Alissa Olga Lukomskyj, N Narasimha Rao, Lei Yan, Jasmine Sarah Pye, Haiyan Li, Bin Wang, Jiao Jiao Li

stem cell-based tissue engineering burn wound treatment mesenchymal stromal cells adipose tissue bone marrow umbilical cord biomaterial scaffolds skin wound repair stem cells MSCs

Studysummary This review of stem cell-based tissue engineering treatments in preclinical burn wound models reports promising improvements in skin repair, suggesting potential as an enhanced therapy for burn wounds.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Stem Cell Therapy for Burns: The Story So Far

24 citations , August 2021 in “Biologics”

This review discusses the use of stem cells and stem cell-derived products in burn wound healing, highlighting various stem cell sources, associated signaling pathways, and delivery methods, but reports no new clinical results.

research Skin Organoids: A New Human Model for Developmental and Translational Research

31 citations , January 2021 in “Experimental Dermatology”

This review discusses recent advancements in generating appendage-bearing skin organoids from pluripotent stem cells and their potential applications in dermatological research, but reports no new clinical results.

research Regeneration of Skin Appendages and Nerves: Current Status and Further Challenges

71 citations , February 2020 in “Journal of Translational Medicine”

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.

research IGF1 and BM-MSC Incorporating Collagen-Chitosan Scaffolds Promote Wound Healing and Hair Follicle Regeneration

3 citations , January 2020 in “PubMed”

This study found that using insulin-like growth factor 1 with bone marrow-derived mesenchymal stem cells in a collagen-chitosan scaffold enhanced wound healing and hair follicle regeneration in rats.

research Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids

169 citations , January 2018 in “Cell Reports”

In this study, researchers successfully derived skin organoids from mouse pluripotent stem cells that spontaneously produce hair follicles, potentially aiding in hair growth research and in vitro drug testing.

Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

research Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

68 citations , August 2014 in “Stem Cells Translational Medicine”

This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.

research Development of a Chitosan Nanofibrillar Scaffold for Skin Repair and Regeneration

162 citations , July 2011 in “Biomacromolecules”

This study found that chitosan nanofibrillar scaffolds accelerated skin wound healing in mice by enhancing cell adhesion, proliferation, and regeneration of epidermis and dermis compared to other forms.

research More Than One Way to Skin

218 citations , April 2008 in “Genes & Development”

This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.