Cutaneous Wound Healing: Canine Allogeneic ASC Therapy

June 2020 in “ Stem Cell Research & Therapy ”

Nathaly Enciso, Luis Avedillo, María Luisa Fermín, Cristina Fragío, C Tejero

cutaneous wound healing allogeneic mesenchymal stem cells adipose tissue skin wound healing wound contraction re-epithelialization adipose mesenchymal stem cells inflammatory infiltrate hair follicles epidermal regeneration dermal regeneration fat tissue wound healing stem cells inflammation hair growth skin regeneration

TLDR Using stem cells from fat tissue can significantly improve wound healing in dogs.

In 2020, Enciso et al. conducted a study on 24 dogs with acute and chronic wounds to evaluate the effectiveness and safety of using cultured allogenic mesenchymal stem cells (MSCs) from adipose tissue (AT) for skin wound healing. The results showed significant improvement in wound contraction and re-epithelialization in wounds treated with adipose mesenchymal stem cells (ASCs) compared to control wounds. By day 90, re-epithelization of both acute and chronic wounds reached over 97%. Histopathological studies revealed a reduction in inflammatory infiltrate and the presence of multiple hair follicles 7 days after ASC treatment, indicating promotion of epidermal and dermal regeneration. The study concluded that allogenic ASC therapy could improve wound healing in dogs and potentially have a clinical impact in human treatment.

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