Human Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Encapsulated in Pluronic F127 Hydrogel Promote Wound Healing and Regeneration

August 2022 in “ Stem Cell Research & Therapy ”

Yang Zhou, Xing-liao Zhang, Shoutao Lu, Ningyan Zhang, Haijun Zhang, Jing Zhang, Jun Zhang

human adipose-derived mesenchymal stem cells exosomes Pluronic F127 hydrogel wound healing re-epithelialization collagen synthesis inflammation reduction skin barrier function hADSCs PF-127

TLDR Encapsulated stem cell exosomes in hydrogel improve wound healing.

The study investigated the use of human adipose-derived mesenchymal stem cells-derived exosomes (hADSCs-Exos) encapsulated in Pluronic F127 hydrogel (PF-127) to enhance wound healing and regeneration in a mouse model. The PF-127/hADSCs-Exos treatment significantly improved cell proliferation, angiogenesis, collagen synthesis, and skin barrier repair, while also reducing inflammation. The hydrogel allowed for sustained release and prolonged retention of exosomes, leading to effective therapeutic outcomes with less frequent application compared to exosomes alone. The study involved 24 mice and demonstrated the potential of this combination as a promising strategy for tissue regeneration and wound healing.

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