Human Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Encapsulated in Pluronic F127 Hydrogel Promote Wound Healing and Regeneration

August 2022 in “ Stem Cell Research & Therapy ”

Yang Zhou, Xing-liao Zhang, Shoutao Lu, Ningyan Zhang, Haijun Zhang, Jing Zhang, Jun Zhang

human adipose-derived mesenchymal stem cells exosomes Pluronic F127 hydrogel wound healing re-epithelialization collagen synthesis inflammation reduction skin barrier function hADSCs PF-127

TLDR Encapsulated stem cell exosomes in hydrogel improve wound healing.

The study investigated the use of human adipose-derived mesenchymal stem cells-derived exosomes (hADSCs-Exos) encapsulated in Pluronic F-127 hydrogel for wound healing. The results showed that this combination enhanced skin wound healing in mice by promoting re-epithelialization, increasing the expression of proteins related to cell proliferation and skin barrier function, facilitating collagen synthesis, and reducing inflammation. The encapsulation in PF-127 hydrogel improved the delivery and bioactivity of hADSCs-Exos, allowing for lower dose administration while maintaining therapeutic effects. This approach was suggested as a promising treatment for skin wound rejuvenation.

View this study on stemcellres.biomedcentral.com →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

research AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

17 citations , March 2021 in “Expert Opinion on Biological Therapy”

Use PRP and ASC-BT for hair loss and wound healing, but more research needed.

Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma, and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

research Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma, and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

70 citations , February 2021 in “International Journal of Molecular Sciences”

Fat-derived stem cells, platelet-rich plasma, and biomaterials show promise for healing chronic skin wounds and improving soft tissue with few side effects.

research Systematic Review: Allogenic Use of Stromal Vascular Fraction and Decellularized Extracellular Matrices as Advanced Therapy Medicinal Products in Tissue Regeneration

113 citations , July 2020 in “International Journal of Molecular Sciences”

Allogenic ASCs and ECM transplants are safe and effective for tissue regeneration.

research Impact of Different Preparation Methods to Obtain Human Adipose-Derived Stromal Vascular Fraction Cells and Human Adipose-Derived Mesenchymal Stem Cells: Enzymatic Digestion Versus Mechanical Centrifugation

124 citations , November 2019 in “International Journal of Molecular Sciences”

Standardized kits improve the quality and consistency of isolating stem cells from fat tissue.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations , July 2019 in “International Journal of Molecular Sciences”

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

research Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration

212 citations , January 2017 in “Mediators of Inflammation”

Stem cells show promise in speeding up wound healing and tissue regeneration.

research Wound Healing and Skin Regeneration

359 citations , January 2015 in “Cold Spring Harbor Perspectives in Medicine”

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.

Related Community Posts Join

6 / 1000+ results

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 446 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community My progress with various products and without oral fin or oral dut on 17 months

in Progress Pictures 61 upvotes 6 months ago

The user shared their hair loss treatment progress using topical products like exosomes, fluridil, Kx826, and topical dutasteride, avoiding oral finasteride and dutasteride due to side effects. They found exosomes from Creative Biolabs most effective and also used topical probiotics, noting improvements without significant side effects.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 84 upvotes 1 year ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

in Treatment 443 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

community IT ABSOLUTELY FUCKING SUCKS to be going through this in silence while my roommates/best friends don't have to worry about this.

in Chat 145 upvotes 5 years ago

The conversation is about a person struggling with hair loss and feeling frustrated comparing themselves to friends with thick hair. They started taking 1 mg Finasteride a month ago to address the hair loss.

Similar Research

6 / 1000+ results

research MSCs and Their Exosomes: A Rapidly Evolving Approach in the Context of Cutaneous Wound Therapy

25 citations , December 2021 in “Stem Cell Research & Therapy”

MSCs and their exosomes may speed up skin wound healing but need more research for consistent use.

Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders

research Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders

December 2024 in “International Journal of Molecular Sciences”

Human umbilical cord stem cell vesicles may help treat aging and related diseases.

research Hydrogel-Mediated Extracellular Vesicles for Enhanced Wound Healing: The Latest Progress and Their Prospects for 3D Bioprinting

1 citations , February 2024 in “Journal of nanobiotechnology”

Hydrogels combined with extracellular vesicles and 3D bioprinting improve wound healing.

research Exosomes: A Promising Strategy for Repair, Regeneration and Treatment of Skin Disorders

1 citations , June 2023 in “Cells”

Exosomes could be a promising way to help repair skin and treat skin disorders.

Human Adipose Tissue-Derived Small Extracellular Vesicles Promote Soft Tissue Repair Through Modulating M1-To-M2 Polarization Of Macrophages

research Human Adipose Tissue-Derived Small Extracellular Vesicles Promote Soft Tissue Repair Through Modulating M1-To-M2 Polarization Of Macrophages

2 citations , April 2023 in “Stem Cell Research & Therapy”

Tiny fat-derived particles can help repair soft tissues by changing immune cell types.

research Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions

10 citations , September 2021 in “International Journal of Nanomedicine”

Tiny particles called extracellular vesicles show promise for treating skin conditions and promoting hair growth.