Human Adipose Tissue-Derived Small Extracellular Vesicles Promote Soft Tissue Repair Through Modulating M1-To-M2 Polarization Of Macrophages

    April 2023 in “ Stem Cell Research & Therapy ”
    Jia Dong, Bin Wu, Weidong Tian
    Image of study
    TLDR Tiny fat-derived particles can help repair soft tissues by changing immune cell types.
    The study explored the role of human adipose tissue-derived small extracellular vesicles (h-sEV-AT) in soft tissue repair. These vesicles were isolated from liposuction adipose tissue and found to increase adipogenesis and angiogenesis in vitro, and induce adipose tissue regeneration and accelerate skin wound healing in vivo. They also increased the percentage of M2 macrophages, which contribute to tissue repair and regeneration. The study concluded that h-sEV-AT can promote soft tissue repair by inducing the differentiation of adipose-derived stromal/stem cells and endothelial cells, and the polarization of macrophages. This suggests a potential cell-free strategy for soft tissue regeneration using these vesicles. However, the specific components of h-sEV-AT that play a key role in soft tissue repair need further identification. The number of participants or samples was not specified.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 855 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Topical finasteride now the safest possible path?

      in Finasteride/Dutasteride  83 upvotes 5 months ago
      Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

      community Having androgen receptor density and sensitivity at wrong f*ing place

      in Satire  7 upvotes 2 months ago
      The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

      community Why only the top of the head?!

      in Chat 2 years ago
      Why the top of the head is affected by hair loss more than other areas, and treatments such as surgery, medications like minoxidil, finasteride, and RU58841 to treat it.

    Similar Research

    5 / 1000+ results