Human Adipose Tissue-Derived Small Extracellular Vesicles Promote Soft Tissue Repair Through Modulating M1-To-M2 Polarization Of Macrophages

    April 2023 in “ Stem Cell Research & Therapy ”
    Jia Dong, Bin Wu, Weidong Tian
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    TLDR Tiny fat-derived particles can help repair soft tissues by changing immune cell types.
    The study explored the role of human adipose tissue-derived small extracellular vesicles (h-sEV-AT) in soft tissue repair. These vesicles were isolated from liposuction adipose tissue and found to increase adipogenesis and angiogenesis in vitro, and induce adipose tissue regeneration and accelerate skin wound healing in vivo. They also increased the percentage of M2 macrophages, which contribute to tissue repair and regeneration. The study concluded that h-sEV-AT can promote soft tissue repair by inducing the differentiation of adipose-derived stromal/stem cells and endothelial cells, and the polarization of macrophages. This suggests a potential cell-free strategy for soft tissue regeneration using these vesicles. However, the specific components of h-sEV-AT that play a key role in soft tissue repair need further identification. The number of participants or samples was not specified.
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