Comparison of the Therapeutic Effect of Allogeneic and Xenogeneic Small Extracellular Vesicles in Soft Tissue Repair

The study investigated the effects of small extracellular vesicles (sEVs) derived from adipose tissue on soft tissue repair, comparing allogeneic sEVs (from the same species) to xenogeneic sEVs (from a different species). It was found that both types of sEVs significantly enhanced wound re-epithelialization, granulation tissue formation, and hair follicle regeneration, thereby accelerating skin wound healing. There was no significant difference in the therapeutic outcomes between allogeneic and xenogeneic sEVs, indicating that the species of origin may not be crucial for the sEVs' function in tissue repair. The study suggests that xenogeneic sEVs, such as those from porcine sources, could be viable for clinical use due to their abundance, high yield, and effectiveness. However, the number of subjects used in the study was not mentioned in the summary.