Bio-Pulsed Stimulation Effectively Improves the Production of Avian Mesenchymal Stem Cell-Derived Extracellular Vesicles That Enhance the Bioactivity of Skin Fibroblasts and Hair Follicle Cells
November 2022
in “
International journal of molecular sciences
”
bio-pulsed small extracellular vesicles sEVs avian mesenchymal stem cells AMSCs Polygonum multiflorum Thunb extract exosomal proteins RNAs human skin fibroblasts HSFs human follicle dermal papilla cells HFDPCs cell proliferation wound healing collagen expression anti-inflammation hair follicle activity follicle activity-associated genes cell proliferative genes apoptosis genes skin regeneration hair regeneration Polygonum multiflorum
TLDR Bio-pulsed stimulation increases production of beneficial vesicles from bird stem cells that improve skin and hair cell functions.
The study investigated the effects of bio-pulsed small extracellular vesicles (sEVs) derived from avian mesenchymal stem cells (AMSCs) on skin fibroblasts and hair follicle cells. The AMSCs were treated with Polygonum multiflorum Thunb extract, resulting in AMSC-sEVs that contained more exosomal proteins and RNAs than the control. These bio-pulsed AMSC-sEVs significantly enhanced cell proliferation, wound healing, collagen expression, and anti-inflammation in human skin fibroblasts (HSFs) and human follicle dermal papilla cells (HFDPCs). They also improved hair follicle activity by upregulating the expression of follicle activity-associated genes and cell proliferative genes, and decreasing the expression of apoptosis genes. The study suggests potential applications of bio-pulsed AMSC-sEVs in skin and hair regeneration therapies.
