Stem Cell Therapy for Burns: The Story So Far

August 2021 in “ Biologics ”

Najath Abdul Kareem, Ayesha Aijaz, Marc G. Jeschke

mesenchymal stem cells bone marrow adipose tissue umbilical cord wound healing scarring skin regeneration growth factors inflammation angiogenesis MSCs

Studysummary This review discusses the use of stem cells and stem cell-derived products in burn wound healing, highlighting various stem cell sources, associated signaling pathways, and delivery methods, but reports no new clinical results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Efficacy of Stem Cell Therapy for Burn Wounds: A Systematic Review and Meta-Analysis of Preclinical Studies

15 citations , July 2020 in “Stem Cell Research & Therapy”

This study found that stem cell therapy significantly improved burn healing rates in animal models, with hair follicle stem cells showing particularly strong effects.

research Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

139 citations , May 2020 in “Stem Cell Research & Therapy”

In this study, human bone marrow mesenchymal stem cell-derived exosomes significantly accelerated cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.

research Effects of Hair Follicle Stem Cells on Partial-Thickness Burn Wound Healing and Tensile Strength

38 citations , December 2019 in “Iranian Biomedical Journal”

This study found that hair follicle stem cells could enhance burn wound healing and improve tissue tensile strength in rats.

research Wnt and Notch Signaling Pathway Involved in Wound Healing by Targeting c-Myc and Hes1 Separately

113 citations , June 2015 in “Stem Cell Research & Therapy”

This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.

research 25 Years of Epidermal Stem Cell Research

55 citations , March 2012 in “Journal of Investigative Dermatology”

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations , November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that in the absence of hair follicles, cutaneous wounds in mice showed delayed reepithelialization but eventually achieved normal wound closure after expanding the activated epidermis region.