Studysummary In this study, autologous platelet-rich plasma improved skin wound healing in mice, associated with reduced inflammation and enhanced angiogenesis and re-epithelialization, but the underlying regulatory mechanism requires further investigation.
The study concluded that platelet-rich plasma (PRP) significantly accelerated skin wound healing by promoting re-epithelialization, enhancing angiogenesis, and facilitating wound contraction and collagen deposition. Conducted on C57/BL6 mice with 5 subjects per group, the research demonstrated that PRP reduced inflammatory cytokines like IL-17 and IL-1β, increased local vessel intensity, and enhanced the secretion of growth factors such as VEGF and IGF-1. PRP also improved the survival, migration, and proliferation of epidermal stem cells, aiding their differentiation into adult cells. These findings provided a preliminary foundation for the clinical use of PRP in wound healing, although further investigation into the underlying mechanisms was needed.
71 citations
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February 2020 in “Journal of Translational Medicine” This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.
44 citations
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February 2020 in “Expert Opinion on Biological Therapy” In this study, autologous non-activated platelet-rich plasma was associated with greater hair re-growth than autologous activated platelet-rich plasma over long-term follow-up.
16 citations
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December 2019 in “Journal of Cellular and Molecular Medicine” This study found that sonicated platelet-rich plasma was more effective than calcium chloride-induced platelet-rich plasma in activating hair follicle stem cells and promoting hair follicle regeneration in mice.
4 citations
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October 2019 in “Skin appendage disorders” This study found that autologous activated PRP injections significantly increased hair density in patients with androgenetic alopecia, with patients reporting high satisfaction and few side effects.
14 citations
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March 2019 in “Journal of Cosmetic Dermatology” This laboratory study found that activated platelet‐rich plasma supernatant enhanced hair growth signaling pathways in cultured human dermal papilla cells, suggesting potential for treating androgenic alopecia.
87 citations
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February 2019 in “Tissue Engineering Part B Reviews” This review discusses the antibacterial properties of platelet-rich plasma (PRP) and summarizes existing preclinical and clinical research on its use for preventing and treating wound and bone infections, but presents no novel data.
