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    Glossary Myofibroblast Differentiation

    process where fibroblasts transform into wound-healing myofibroblasts

    Myofibroblast differentiation is the process by which fibroblasts, a type of cell found in connective tissue, transform into myofibroblasts. These myofibroblasts play a crucial role in wound healing and tissue repair by contracting and producing extracellular matrix components, which help close wounds and restore tissue integrity. However, excessive myofibroblast activity can lead to fibrosis, a condition characterized by excessive tissue scarring.

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    1. Dendritic Cell–Associated MARCKSL1 Regulates Fibroblast Differentiation During Wound Healing Wound Repair and Regeneration · 2026
    2. Effect of Chlorhexidine Digluconate in Early Wound Healing of Human Gingival Tissues. A Histological, Immunohistochemical and Biomolecular Analysis Antibiotics · 2021 · 31 citations
    3. Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing Frontiers in Immunology · 2022 · 20 citations
    4. Dual-Action Icariin-Containing Thermosensitive Hydrogel for Wound Macrophage Polarization and Hair-Follicle Neogenesis Frontiers in Bioengineering and Biotechnology · 2022 · 6 citations
    5. Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors To Improve Skin Regeneration ACS Applied Bio Materials · 2019 · 5 citations
    6. The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair International journal of molecular sciences · 2024 · 1 citations
    7. Dermal Fibrosis and the Current Scope of Hydrogel Strategies for Scarless Wound Healing Fibrosis · 2024 · 1 citations
    8. The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring Pharmaceutics · 2023 · 1 citations
    9. Retinoids in scarless skin regeneration: from molecular mechanisms to therapeutic strategies Frontiers in Cell and Developmental Biology · 2025
    10. Recombinant Human Annexin A5 Ameliorates Localized Scleroderma by Inhibiting the Activation of Fibroblasts and Macrophages Pharmaceutics · 2025
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