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    Glossary Myofibroblast Differentiation

    process where fibroblasts transform into wound-healing myofibroblasts

    Myofibroblast differentiation is the process by which fibroblasts, a type of cell found in connective tissue, transform into myofibroblasts. These myofibroblasts play a crucial role in wound healing and tissue repair by contracting and producing extracellular matrix components, which help close wounds and restore tissue integrity. However, excessive myofibroblast activity can lead to fibrosis, a condition characterized by excessive tissue scarring.

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    1. Dendritic Cell–Associated MARCKSL1 Regulates Fibroblast Differentiation During Wound Healing Wound Repair and Regeneration · 2026
    2. Effect of Chlorhexidine Digluconate in Early Wound Healing of Human Gingival Tissues. A Histological, Immunohistochemical and Biomolecular Analysis Antibiotics · 2021 · 31 citations
    3. Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing Frontiers in Immunology · 2022 · 20 citations
    4. Dual-Action Icariin-Containing Thermosensitive Hydrogel for Wound Macrophage Polarization and Hair-Follicle Neogenesis Frontiers in Bioengineering and Biotechnology · 2022 · 6 citations
    5. Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors To Improve Skin Regeneration ACS Applied Bio Materials · 2019 · 5 citations
    6. The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair International journal of molecular sciences · 2024 · 1 citations
    7. Dermal Fibrosis and the Current Scope of Hydrogel Strategies for Scarless Wound Healing Fibrosis · 2024 · 1 citations
    8. The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring Pharmaceutics · 2023 · 1 citations
    9. Retinoids in scarless skin regeneration: from molecular mechanisms to therapeutic strategies Frontiers in Cell and Developmental Biology · 2025
    10. Recombinant Human Annexin A5 Ameliorates Localized Scleroderma by Inhibiting the Activation of Fibroblasts and Macrophages Pharmaceutics · 2025
    11. 0874 TGF-β signaling-mediated wound healing is required for hair follicle neogenesis Journal of Investigative Dermatology · 2025
    12. Self-Organizing 3D Dermal Papilla Cell Spheroids Yield Therapeutic Extracellular Vesicles that Target Hypertrophic Scar Regression via the miR-26a-5p/CCNE2 Axis Burns & Trauma · 2025
    13. Signalling Underlying Wound Healing Encyclopedia of Life Sciences · 2019
    14. 14. Wound Healing; Cutaneous Therapy; Hair Medical & surgical dermatology · 2008
    15. Epigenetic regulations on skin wound healing: implications from current researches. PubMed · 2015 · 5 citations
    16. Issue Information Experimental Dermatology · 2020
    17. Data Sheet 1_SHP099-containing multi-targeting hydrogel promotes rapid skin reconstruction through modulating a variety of cells.zip Figshare · 2025
    18. Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration Frontiers in Cell and Developmental Biology · 2021 · 74 citations
    19. CD201+ fascia progenitors choreograph injury repair Research Square (Research Square) · 2022 · 5 citations
    20. Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors Journal of Cell Communication and Signaling · 2014 · 21 citations
    21. Rare Gli1+ perivascular fibroblasts promote skin wound repair bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 2 citations
    22. States and Fates of Skin Fibroblasts Revealed through Chromatin Accessibility Journal of Investigative Dermatology · 2022
    23. Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration Cell Reports · 2023 · 44 citations
    24. 974 Single-cell analysis identifies heterogeneity of fibroblasts and myeloid-derived adipocytes in regenerating mouse skin wounds 2019 · 1 citations
    25. Development of a 3D In Vitro Model of Dupuytren’s Disease as a Platform for Drug Screening Cellular and Molecular Bioengineering · 2026
    26. Scarless wound healing: finding the right cells and signals Cell and Tissue Research · 2016 · 132 citations
    27. 4-Aminopyridine Induces Nerve Growth Factor to Improve Skin Wound Healing and Tissue Regeneration Biomedicines · 2022
    28. Epigenetic control of skin and hair regeneration after wounding Experimental Dermatology · 2014 · 36 citations
    29. General theory of skin reinforcement PLOS ONE · 2017 · 18 citations
    30. Effects of porcine acellular dermal matrix treatment on wound healing and scar formation: Role of Jag1 expression in epidermal stem cells Organogenesis · 2018 · 10 citations