Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

October 2022 in “ International Journal of Molecular Sciences ”

Jung Eun Kim, Yu-Jin Lee, Kyung-Jae Lee, Song-Hee Park, Hoon Kang

Alopecia Areata allogenic mesenchymal stem cells peripheral blood mononuclear cells CD4+INF-γ+ T cells CD4+Foxp3+ regulatory T cells proinflammatory cytokines chemokines immune tolerance anti-inflammatory effects AA hMSCs PBMCs regulatory T cells anti-inflammatory

TLDR Using healthy donor stem cells can potentially calm overactive immune cells and reduce inflammation in severe hair loss patients, offering a possible treatment method.

The study involved 10 severe Alopecia Areata (AA) patients and investigated the effects of allogenic human mesenchymal stem cells (hMSCs) from healthy donors on the patients' peripheral blood mononuclear cells (PBMCs). The results showed that co-culturing with hMSCs suppressed the activation levels of CD4+INF-γ+ T cells and induced the differentiation of CD4+Foxp3+ regulatory T cells in AA patients. The hMSC treatment also significantly inhibited the mRNA levels of proinflammatory cytokines and chemokines. These findings suggest that allogenic hMSC treatments could potentially induce immune tolerance and anti-inflammatory effects in severe AA patients, offering a potential therapeutic approach.

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1 / 1 results

research Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata

1 citations , October 2022 in “International Journal of Molecular Sciences”

Using healthy donor stem cells can potentially calm overactive immune cells and reduce inflammation in severe hair loss patients, offering a possible treatment method.