Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata

    April 2021 in “ JCI insight ”
    Zhijun Dai, James Chen, Yi‐Lu Chang, Angela M. Christiano
    Studysummary In this study, selective inhibition of JAK3 signaling effectively prevented and reversed alopecia areata in a mouse model, while JAK2 inhibitors did not restore hair growth.
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    Research cited in this study 11

    1. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    2. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    3. CXCR3 Blockade Inhibits T Cell Migration Into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016
    4. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    5. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    6. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    7. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    8. Type 1 Interferon Signature in the Scalp Lesions of Alopecia Areata British Journal of Dermatology · 2010
    9. Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata Journal of Clinical Investigation · 2007
    10. Interleukin-10-Deficient Mice Are Less Susceptible to the Induction of Alopecia Areata Journal of Investigative Dermatology · 2002
    11. Alopecia Areata: Clinical Review and Treatment Approaches American Journal of Clinical Dermatology · 2000