Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata

The study demonstrated that selective inhibition of JAK3 signaling was sufficient to reverse alopecia areata (AA) in C3H/HeJ mice. Researchers found that JAK3 inhibitors promoted robust hair regrowth and significantly reduced skin inflammation and CD8+ T cell infiltration, while JAK2 inhibitors did not restore hair growth. The findings highlighted the critical role of JAK1 and JAK3 in AA pathogenesis, suggesting that targeting these pathways could be an effective treatment strategy. The study involved multiple experiments with groups of 4 to 10 mice, reinforcing the potential of JAK3 inhibitors in treating AA.