Discovery Of A Novel And Highly Selective JAK3 Inhibitor As A Potent Hair Growth Promoter

April 2024 in “ Journal of translational medicine ”

Md Mehedi Hossain, Arfan Khalid, Zaheen Akhter, Sabra Parveen, Mir Owais Ayaz, Aadil Qadir Bhat, Neetu Badesra, Farheen Showket, Mohmmad Saleem Dar, Farhan Ahmed, Sumit Dhiman, Mukesh Kumar, Umed Singh, Razak Hussain, Pankaj Keshari, Ghulam Mustafa, Amit Nargorta, Neha Taneja, Surabhi Gupta, Riyaz Ahmad Mir, Aravind Kshatri, Utpal Nandi, Nooruddin Khan, P. Ramajayan, Govind Yadav, Zabeer Ahmed, Parvinder Pal Singh, Mohd Jamal Dar

JAK3 inhibitor MJ04 hair growth promoter IC50 DHT androgenetic alopecia athymic nude mice human hair follicle growth pharmacokinetic profiles safety profiles in vivo tests in vitro tests JAK3 STAT3 phosphorylation proinflammatory cytokine levels hair loss conditions hair loss

Studysummary In this study, the researchers identified MJ04, a selective JAK3 inhibitor, as a promising candidate for promoting hair growth, demonstrating efficacy in both animal models and human hair follicle assays with a favorable safety and pharmacokinetic profile. Our plain-language summary of this paper — not a Tressless recommendation.

The study discovered MJ04, a novel and highly selective JAK3 inhibitor, as a potent hair growth promoter with an IC50 of 2.03 nM. MJ04 showed significant hair regrowth in DHT-challenged androgenetic alopecia and athymic nude mice, and promoted human hair follicle growth ex vivo. It demonstrated good pharmacokinetic and safety profiles, with no adverse effects in both in vivo and in vitro tests. MJ04 effectively inhibited JAK3 and STAT3 phosphorylation, reduced proinflammatory cytokine levels, and induced rapid hair growth, suggesting its potential as a therapeutic agent for treating hair loss conditions.

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