Alopecia Areata: Current Treatments and New Directions

August 2023 in “ American Journal of Clinical Dermatology ”

Dante Dahabreh, Seungyeon Jung, Yael Renert‐Yuval, Jonathan Bar, Ester Del Duca, Emma Guttman‐Yassky

alopecia areata latanoprost bimatoprost interleukin-2 T-regulatory cells platelet-rich plasma PRP plasmacytoid dendritic cells JAK inhibitors upadacitinib alopecia universalis eyelash growth solutions low-dose IL-2 hair regrowth randomized controlled trials severe alopecia hair loss treatments

TLDR JAK inhibitors and platelet-rich plasma show promise for treating alopecia areata.

The document reviews current and emerging treatments for alopecia areata, noting the limited efficacy of topical solutions like latanoprost and bimatoprost for eyelash growth. It highlights the potential of low-dose interleukin-2 to promote T-regulatory cells and the promising results of platelet-rich plasma (PRP) in hair regrowth, supported by various studies, including randomized controlled trials. The role of plasmacytoid dendritic cells and the economic burden of alopecia areata are also explored. JAK inhibitors, such as upadacitinib, have shown success in treating severe cases, including alopecia universalis. The review emphasizes the need for further research to validate these treatments and improve patient outcomes.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

99 / 99 results

research Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial

227 citations , April 2023 in “The Lancet”

Ritlecitinib effectively treats alopecia areata and is well-tolerated.

research Upadacitinib for Management of Recalcitrant Alopecia Areata: A Retrospective Case Series

3 citations , March 2023 in “JAAD case reports”

Upadacitinib cleared scalp alopecia areata in three patients and also improved atopic dermatitis with minimal side effects.

research Treatment of Alopecia Areata With the Janus Kinase Inhibitor Upadacitinib: A Retrospective Cohort Study

6 citations , February 2023 in “Journal of the American Academy of Dermatology”

Upadacitinib improved hair regrowth and quality of life in alopecia areata patients with minimal side effects.

Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib: A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata

research Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib: A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata

9 citations , January 2023 in “Dermatology and therapy”

A 14-year-old girl with severe hair loss regrew her hair using upadacitinib.

research Scalp Biomarkers During Dupilumab Treatment Support Th2 Pathway Pathogenicity in Alopecia Areata

15 citations , October 2022 in “Allergy”

Dupilumab treatment reduces Th2-related markers and helps hair growth in alopecia areata, showing Th2's role in the condition.

research An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata

40 citations , August 2022 in “Frontiers in immunology”

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

research The Efficacy and Safety of JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis of Prospective Studies

37 citations , August 2022 in “Frontiers in pharmacology”

Oral JAK inhibitors are effective and safe for treating alopecia areata but may need ongoing use to keep results.

research Analysis of Alopecia Areata Surveys Suggests a Threshold for Improved Patient-Reported Outcomes

14 citations , June 2022 in “British Journal of Dermatology”

A SALT score of ≤ 20 indicates meaningful improvement in alopecia areata treatment.

research Economic Burden and Healthcare Resource Use of Alopecia Areata in an Insured Population in the USA

12 citations , April 2022 in “Dermatology and therapy”

Alopecia areata leads to significantly higher healthcare costs due to more doctor visits and prescriptions.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

Baricitinib was effective in treating alopecia areata in two major trials.

research Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata

49 citations , February 2022 in “Drug Design Development and Therapy”

Ritlecitinib shows promise for hair regrowth in alopecia areata patients.

research Upadacitinib for the Treatment of Alopecia Areata and Severe Atopic Dermatitis in a Pediatric Patient: A Case Report

7 citations , January 2022 in “SAGE open medical case reports”

Upadacitinib successfully treated a child's severe skin and hair loss issues.

research Alopecia Areata: Current Understanding and Management

11 citations , January 2022 in “Journal der Deutschen Dermatologischen Gesellschaft”

Alopecia areata is a chronic condition causing hair loss, with new treatments targeting the immune system showing promise.

research Maintenance, Withdrawal, and Re-Treatment with Ritlecitinib and Brepocitinib in Patients with Alopecia Areata in a Single-Blind Extension of a Phase 2a Randomized Clinical Trial

20 citations , December 2021 in “Journal of the American Academy of Dermatology”

Continuous treatment with ritlecitinib and brepocitinib is needed to maintain hair regrowth in alopecia areata.

research Ritlecitinib And Brepocitinib Demonstrate Significant Improvement In Scalp Alopecia Areata Biomarkers

36 citations , December 2021 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Two drugs, ritlecitinib and brepocitinib, improved scalp hair loss condition markers.

research Validation of the Alopecia Areata Patient Priority Outcomes Questionnaire in Adults and Adolescents with Alopecia Areata

22 citations , November 2021 in “Dermatology and Therapy”

The AAPPO questionnaire is a reliable tool for assessing hair loss impact in alopecia areata patients.

research Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management

290 citations , August 2021 in “Clinical Reviews in Allergy & Immunology”

JAK inhibitors show promise for treating alopecia areata, but more research is needed.

Efficacy and Safety of the Oral Janus Kinase Inhibitor Baricitinib in the Treatment of Adults with Alopecia Areata: Phase 2 Results from a Randomized Controlled Study

research Efficacy and Safety of the Oral Janus Kinase Inhibitor Baricitinib in the Treatment of Adults with Alopecia Areata: Phase 2 Results from a Randomized Controlled Study

66 citations , June 2021 in “Journal of The American Academy of Dermatology”

Baricitinib is effective and safe for treating severe alopecia areata.

research Resident Memory T Cells in Autoimmune Skin Diseases

50 citations , May 2021 in “Frontiers in immunology”

Certain immune cells contribute to skin autoimmune diseases, and some treatments can reverse hair loss in these conditions.

research A Phase 2a Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of the Oral Janus Kinase Inhibitors Ritlecitinib and Brepocitinib in Alopecia Areata: 24-Week Results

138 citations , March 2021 in “Journal of the American Academy of Dermatology”

Ritlecitinib and brepocitinib effectively regrow hair in alopecia areata patients.

research Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update

20 citations , March 2021 in “Drug design, development and therapy”

Topical immunotherapy can treat alopecia areata, but its effectiveness varies and the exact mechanism is unclear.

research Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options

56 citations , January 2021 in “Clinical and Experimental Medicine”

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

research Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing Its Impact on T Regulatory Cell and NK Cell Populations

22 citations , September 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study's results on the effectiveness of low-dose IL-2 for alopecia areata and its impact on immune cells were not provided.

research Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata

134 citations , July 2020 in “Experimental dermatology”

Hair follicles are normally protected from the immune system, but when this protection fails, it can cause hair loss in alopecia areata.

Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study

research Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study

10 citations , April 2020 in “Dermatology and therapy”

Calcipotriol works almost as well as clobetasol for mild to moderate alopecia areata with fewer side effects.

research Efficacy of Different Concentrations of Intralesional Triamcinolone Acetonide for Alopecia Areata: A Systematic Review and Meta-Analysis

19 citations , April 2020 in “Journal of the American Academy of Dermatology”

5 mg/mL of triamcinolone acetonide is most effective for hair regrowth with fewer side effects.

research Platelet-Rich Plasma Accelerates Skin Wound Healing by Promoting Re-Epithelialization

169 citations , January 2020 in “Burns & Trauma”

Platelet-rich plasma speeds up skin wound healing.

research Platelet-Rich Plasma in Alopecia Areata: Intradermal Injection Versus Topical Application with Transepidermal Delivery via Either Fractional Carbon Dioxide Laser or Microneedling

5 citations , January 2020 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

Injecting platelet-rich plasma or applying it with a laser or microneedling can treat hair loss effectively. The laser and microneedling methods cause less pain.

research IL-12/IL-23 Neutralization Is Ineffective for Alopecia Areata in Mice and Humans

20 citations , December 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Blocking IL-12/IL-23 does not help with hair loss in alopecia areata for mice or humans.

research Targeting the Janus Kinase Family in Autoimmune Skin Diseases

124 citations , October 2019 in “Frontiers in Immunology”

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

research Frontiers in Alopecia Areata Pathobiology Research

55 citations , October 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.

research Benefit and Risk Profile of Tofacitinib for the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis

54 citations , September 2019 in “Journal of the European Academy of Dermatology and Venereology”

Tofacitinib is somewhat effective for alopecia areata, but more research is needed on its safety and long-term effects.

research A Review of Topical Corticosteroid Foams

3 citations , August 2019 in “PubMed”

Topical corticosteroid foams are effective, safe, and easy to use for treating various skin conditions.

$Apremilast Is Efficacious in Refractory Alopecia Areata$

research Apremilast Is Efficacious in Refractory Alopecia Areata

9 citations , May 2019 in “Journal of dermatological treatment”

Apremilast helps regrow hair in hard-to-treat alopecia areata.

research Cyclosporine for Moderate-to-Severe Alopecia Areata: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety

44 citations , April 2019 in “Journal of the American Academy of Dermatology”

Cyclosporine showed some improvement in alopecia areata but results were not statistically significant.

research Minoxidil for Patchy Alopecia Areata: Systematic Review and Meta-Analysis

20 citations , March 2019 in “Journal of The European Academy of Dermatology and Venereology”

Minoxidil effectively and safely treats patchy hair loss, but more research needed.

research JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis

130 citations , February 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

JAK inhibitors are effective for treating alopecia areata, with most patients seeing hair growth after treatment.

research JAK Inhibitors and Alopecia Areata

56 citations , January 2019 in “Lancet”

JAK inhibitors help regrow hair in alopecia areata patients, improving their quality of life.

research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , December 2018 in “Journal of autoimmunity”

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

A Randomized Placebo-Controlled Single-Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects with Moderate-to-Severe Alopecia Areata

research A Randomized Placebo-Controlled Single-Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects with Moderate-to-Severe Alopecia Areata

42 citations , November 2018 in “Archives of dermatological research”

Apremilast was not effective in treating moderate-to-severe alopecia areata.

research Response to Ustekinumab in Three Pediatric Patients with Alopecia Areata

25 citations , October 2018 in “Pediatric dermatology”

Ustekinumab helped three kids with alopecia areata regrow hair.

research Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata

89 citations , August 2018 in “JAMA Dermatology”

Contact immunotherapy can improve hair regrowth in alopecia areata patients.

An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

research An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

130 citations , February 2018 in “Journal of Investigative Dermatology”

Tofacitinib may help treat severe hair loss, but more research is needed.

research Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

102 citations , December 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

research Alopecia Areata: Overview and Insights from January 2018

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

research A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

348 citations , July 2017 in “Skin appendage disorders”

Platelet-rich plasma shows promise for skin and hair treatments but needs more research and standardization.

research The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm

77 citations , June 2017 in “Advances in Therapy”

New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.

research Topical Janus Kinase Inhibitors for the Treatment of Pediatric Alopecia Areata

83 citations , June 2017 in “Journal of the American Academy of Dermatology”

Topical JAK inhibitors may help children with alopecia areata regrow hair.

research The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study

70 citations , February 2017 in “Dermatologic Surgery”

Treatment with plasma rich in growth factors improved hair density and thickness for hair loss patients.

research Sequential High- And Low-Dose Systemic Corticosteroid Therapy For Severe Childhood Alopecia Areata

18 citations , January 2017 in “Journal der Deutschen Dermatologischen Gesellschaft”

High and low doses of prednisolone helped 62% of children with severe alopecia regrow hair with some weight gain and mild acne as side effects.

research A Split Head Study of Efficacy of Placebo Versus Platelet-Rich Plasma Injections in the Treatment of Androgenic Alopecia

33 citations , January 2017 in “Journal of Cutaneous and Aesthetic Surgery”

Platelet-rich plasma injections can effectively treat male pattern hair loss, improving hair density and quality with high patient satisfaction.

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

238 citations , November 2016 in “Journal of The American Academy of Dermatology”

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

research Platelet-Rich Plasma Versus Minoxidil 5% in Treatment of Alopecia Areata: A Trichoscopic Evaluation

62 citations , October 2016 in “Dermatologic Therapy”

PRP more effective than minoxidil 5% for treating alopecia areata.

research Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata

222 citations , September 2016 in “JCI insight”

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

research Familial Aggregation of Alopecia Areata

295 citations , May 2016 in “Journal of the American Academy of Dermatology”

Alopecia areata, a common autoimmune hair loss condition, often runs in families.

Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse

research Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse

36 citations , April 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

A substance called VIP might protect hair follicles from being attacked by the immune system, and problems with VIP signaling could lead to hair loss in alopecia areata.

Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations , April 2016 in “Dermatologic Surgery”

PRP treatment helps hair growth and density in androgenetic alopecia patients.

research A Systematic Review of Pulse Steroid Therapy for Alopecia Areata

50 citations , January 2016 in “Journal of the American Academy of Dermatology”

Pulse steroid therapy for alopecia areata shows a 43% complete response rate but has a high relapse rate, especially in children.

research Biomarkers of Alopecia Areata Disease Activity and Response to Corticosteroid Treatment

65 citations , December 2015 in “Experimental dermatology”

Corticosteroid treatment reduces inflammation and alters hair keratins in alopecia areata.

research Extensive Alopecia Areata Is Reversed by IL-12/IL-23p40 Cytokine Antagonism

68 citations , November 2015 in “The Journal of Allergy and Clinical Immunology”

Blocking IL-12/IL-23p40 helped reverse severe hair loss in patients.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

research A Guide to Studying Human Hair Follicle Cycling In Vivo

212 citations , September 2015 in “Journal of Investigative Dermatology”

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

research The Role of Lymphocytes in the Development and Treatment of Alopecia Areata

60 citations , September 2015 in “Expert Review of Clinical Immunology”

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

research Successful Treatment of Corticosteroid-Resistant Ophiasis-Type Alopecia Areata with Platelet-Rich Plasma

30 citations , August 2015 in “JAAD case reports”

Platelet-rich plasma (PRP) injections successfully treated a woman's steroid-resistant hair loss, causing hair to regrow within a month.

research Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing

176 citations , August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

research Efficacy of Platelet-Rich Plasma in Treatment of Androgenic Alopecia

74 citations , January 2015 in “Asian Journal of Transfusion Science”

Platelet-rich plasma (PRP) injections can effectively increase hair density and thickness in people with androgenic alopecia, without major side effects.

research Comparative Evaluation of Intralesional Triamcinolone Acetonide Injection, Narrow Band Ultraviolet B, and Their Combination in Alopecia Areata

18 citations , January 2015 in “International Journal of Trichology”

Intralesional steroids are more effective for hair regrowth in alopecia areata than NBUVB, but combining them doesn't improve results.

research Intravenous Methylprednisolone Pulse Therapy in Severe Alopecia Areata

14 citations , January 2015 in “Indian journal of dermatology, venereology, and leprology”

Methylprednisolone infusions can help some people with severe alopecia regrow hair.

research Role of Platelet-Rich Plasma in Chronic Alopecia Areata: Our Centre Experience

61 citations , January 2015 in “Indian Journal of Plastic Surgery”

Platelet-rich plasma treatment could potentially be an effective way to treat chronic alopecia areata with minimal side effects.

research Plasmacytoid Dendritic Cells in Alopecia Areata: Missing Link?

45 citations , December 2014 in “Journal of the European Academy of Dermatology and Venereology”

Plasmacytoid dendritic cells are a key factor in causing hair loss in alopecia areata and could help differentiate it from other hair loss conditions.

research Inhibiting Janus Kinases to Treat Alopecia Areata

52 citations , September 2014 in “Nature medicine”

JAK inhibitors might help treat alopecia areata.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

PRP injections increase hair density and satisfaction in androgenetic alopecia patients.

research Platelet-Rich Plasma in Androgenic Alopecia: Myth or Effective Tool

115 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

Platelet-rich plasma (PRP) is a cheap and easy treatment for hair loss, but not suitable for everyone. It also helps in healing ulcers, rejuvenating skin, and improving hair transplants.

A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , April 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

research New Investigational Drugs for Androgenetic Alopecia

48 citations , April 2013 in “Expert Opinion on Investigational Drugs”

Possible new treatments for common hair loss include drugs, stem cells, and improved transplants.

research The Effect of CD34+ Cell-Containing Autologous Platelet-Rich Plasma Injection on Pattern Hair Loss: A Preliminary Study

88 citations , December 2012 in “Journal of The European Academy of Dermatology and Venereology”

Injecting CD34+ cell-containing platelet-rich plasma into the scalp can improve hair count and thickness in people with pattern hair loss.

research Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata

75 citations , October 2012 in “Journal of Investigative Dermatology”

Alopecia areata can be triggered by specific immune cells without genetic or environmental factors.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

research Alopecia Areata: A New Treatment Plan

67 citations , July 2011 in “Clinical, cosmetic and investigational dermatology”

The document suggests a personalized treatment plan for alopecia areata based on the patient's age and hair loss severity, using a range of therapies ranked by effectiveness and safety.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

research Alopecia Areata Update

244 citations , January 2010 in “Journal of the American Academy of Dermatology”

The document says current treatments for alopecia areata do not cure or prevent it, and it's hard to judge their effectiveness due to spontaneous remission and lack of studies.

research Topical Immunotherapy in Alopecia Areata

45 citations , January 2010 in “International journal of trichology”

Topical immunotherapy, especially with DPCP, is effective for treating severe alopecia areata.

research Intralesional Steroids for Alopecia Areata

36 citations , January 2010 in “International Journal of Trichology”

Intralesional steroids can help regrow hair in some alopecia areata patients but have side effects.

research Bimatoprost in the Treatment of Eyelash Universalis Alopecia Areata

37 citations , January 2010 in “International Journal of Trichology”

Bimatoprost helped eyelash growth in nearly half of the patients with a type of eyelash hair loss.

research Latanoprost in the Treatment of Eyelash Alopecia in Alopecia Areata Universalis

50 citations , December 2009 in “Journal of The European Academy of Dermatology and Venereology”

Latanoprost can effectively treat eyelash hair loss, with 45% of patients showing hair regrowth and no reported side effects.

research Treatment of Severe Alopecia Areata with Intralesional Steroid Injections

60 citations , October 2009 in “PubMed”

Intralesional steroid injections are safe and effective for treating severe alopecia areata.

Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata

research Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata

55 citations , March 2009 in “Journal of The American Academy of Dermatology”

Topical latanoprost and bimatoprost eye solutions don't help eyelash growth in people with alopecia areata.

research The Effects of Autologous Platelet-Rich Plasma and Various Growth Factors on Non-Transplanted Miniaturized Hair

37 citations , March 2009 in “Hair transplant forum international”

PRP treatment helped reverse hair thinning and promoted new hair growth.

research The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results

59 citations , September 2008 in “Experimental dermatology”

Both mouse and rat models are effective for testing alopecia areata treatments.

research Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-Mediated Root Sheath Disruption in Advance of Overt Hair Loss

37 citations , November 2003 in “Veterinary pathology”

Hair loss in mice starts with immune cells damaging hair roots before it becomes visible.

research Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans

114 citations , August 2002 in “Journal of Investigative Dermatology”

Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.

research Hair Regrowth

118 citations , April 1998 in “Dermatologic Clinics”

Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.

research Alopecia Areata in Children: Response to Treatment with Diphencyprone

84 citations , August 1991 in “British Journal of Dermatology”

Most children treated with diphencyprone regrew some or all of their hair.

research Immunohistochemical and Electron Microscopic Characterization of the Cellular Infiltrate in Alopecia Areata, Totalis, and Universalis

78 citations , July 1984 in “Journal of Investigative Dermatology”