Alopecia Areata: Current Treatments and New Directions

August 2023 in “ American Journal of Clinical Dermatology ”

Dante Dahabreh, Seungyeon Jung, Yael Renert‐Yuval, Jonathan Bar, Ester Del Duca, Emma Guttman‐Yassky

alopecia areata latanoprost bimatoprost interleukin-2 T-regulatory cells platelet-rich plasma PRP plasmacytoid dendritic cells JAK inhibitors upadacitinib alopecia universalis eyelash growth solutions low-dose IL-2 hair regrowth randomized controlled trials severe alopecia hair loss treatments

TLDR JAK inhibitors and platelet-rich plasma show promise for treating alopecia areata.

The document reviews current and emerging treatments for alopecia areata, noting the limited efficacy of topical solutions like latanoprost and bimatoprost for eyelash growth. It highlights the potential of low-dose interleukin-2 to promote T-regulatory cells and the promising results of platelet-rich plasma (PRP) in hair regrowth, supported by various studies, including randomized controlled trials. The role of plasmacytoid dendritic cells and the economic burden of alopecia areata are also explored. JAK inhibitors, such as upadacitinib, have shown success in treating severe cases, including alopecia universalis. The review emphasizes the need for further research to validate these treatments and improve patient outcomes.

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Research cited in this study

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