Sequential High- And Low-Dose Systemic Corticosteroid Therapy For Severe Childhood Alopecia Areata

    January 2017 in “ Journal der Deutschen Dermatologischen Gesellschaft ”
    Karin Jahn‐Bassler, Wolfgang Bauer, Franz Karlhofer, Matthias G. Vossen, Georg Stingl
    Image of study
    TLDR High and low doses of prednisolone helped 62% of children with severe alopecia regrow hair with some weight gain and mild acne as side effects.
    In a study from 2017, 13 children with severe alopecia areata (AA) were treated with an initial high-dose pulse therapy of prednisolone at 2 mg/kg, which was then tapered to a maintenance dose below the individual Cushing threshold over nine weeks. The children were followed for one to three years. The results showed that 62% of the participants achieved complete hair regrowth, with a mean time to response of 6.6 weeks, and the response was maintained throughout the follow-up period with the maintenance therapy. Side effects included weight gain of 1-3 kg in all children and mild steroid acne in 23% of cases. The study concluded that sequential high- and low-dose prednisolone therapy is an effective and safe treatment for childhood AA.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    6 / 1000+ results

      community Antihistamines stop my hair loss

      in Treatment  23 upvotes 4 years ago
      A user found that antihistamines stop their hair loss and related symptoms, but they experience side effects like sedation and chest pain. They are seeking alternative solutions or topical antihistamines to avoid systemic side effects.

      community I’ve read multiple times that Fin increases hair quality… NOT for me!

      in Treatment  97 upvotes 2 years ago
      A user has been on finasteride for 6 months and feels their hair quality has worsened, experiencing more hair loss and scalp irritation. They are considering seeing a dermatologist, while others suggest the issue might be unrelated to finasteride, possibly due to deficiencies or other conditions.

      community Well here I am 3-4 years later.

      in Update  56 upvotes 2 years ago
      The conversation is about someone who has been taking finasteride for hair loss without success, considering switching to dutasteride or giving up treatment. Suggestions include trying dutasteride, microneedling, infrared therapy, multivitamins, and high-concentration topical solutions combining finasteride and dutasteride.

    Related Research

    1 / 1 results