Sequential High- And Low-Dose Systemic Corticosteroid Therapy For Severe Childhood Alopecia Areata

    January 2017 in “ Journal der Deutschen Dermatologischen Gesellschaft ”
    Karin Jahn‐Bassler, Wolfgang Bauer, Franz Karlhofer, Matthias G. Vossen, Georg Stingl
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    TLDR High and low doses of prednisolone helped 62% of children with severe alopecia regrow hair with some weight gain and mild acne as side effects.
    In a study from 2017, 13 children with severe alopecia areata (AA) were treated with an initial high-dose pulse therapy of prednisolone at 2 mg/kg, which was then tapered to a maintenance dose below the individual Cushing threshold over nine weeks. The children were followed for one to three years. The results showed that 62% of the participants achieved complete hair regrowth, with a mean time to response of 6.6 weeks, and the response was maintained throughout the follow-up period with the maintenance therapy. Side effects included weight gain of 1-3 kg in all children and mild steroid acne in 23% of cases. The study concluded that sequential high- and low-dose prednisolone therapy is an effective and safe treatment for childhood AA.
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