Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-Mediated Root Sheath Disruption in Advance of Overt Hair Loss

    November 2003 in “ Veterinary pathology ”
    Kevin J. McElwee, KÉSSIA CATARINA BELIZIO DA SILVA, Dawnalyn Boggess … John P. Sundberg
    Studysummary This study showed that in C3H/HeJ mice, focal follicular inflammation starts before overt hair loss, with inflammation severity possibly reaching a threshold causing hair follicle dystrophy prior to visible hair loss.
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    Research cited in this study 7

    1. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002
    2. Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata Journal of Investigative Dermatology · 2002
    3. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    4. Cytokines and Growth Factors Influence Hair Growth In Vitro: Possible Implications for the Pathogenesis and Treatment of Alopecia Areata Archives of Dermatological Research · 1996
    5. Alopecia Areata in Aging C3H/HeJ Mice Journal of Investigative Dermatology · 1994
    6. Topical Minoxidil in Alopecia Areata: No Effect on the Perifollicular Lymphoid Infiltration Journal of Investigative Dermatology · 1992
    7. Immunohistochemical and Electron Microscopic Characterization of the Cellular Infiltrate in Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 1984

    Related research 5

    1. Miniaturized Hairs Maintain Contact With the Arrector Pili Muscle in Alopecia Areata but Not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth International Journal of Trichology · 2012
    2. Hair Follicle Stem Cell Marker Nestin Expression in Regenerating Hair Follicles of Patients with Alopecia Areata European Journal of Dermatology · 2011
    3. Hair Follicular Expression of Integrin Alpha-6 Subunit and p63 in Hair Loss Journal of Clinical Dermatology · 2008
    4. Pathogenesis of Alopecia Areata in C3H/HeJ Mice and DEBR Rats 2006
    5. Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-Mediated Root Sheath Disruption in Advance of Overt Hair Loss Veterinary pathology · 2003