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Glossary C3H/HeJ mice

strain of lab mice used for immune and cancer research

C3H/HeJ mice are a specific strain of laboratory mice that are commonly used in scientific research. They have a genetic mutation that makes them resistant to certain bacterial infections, which makes them valuable for studying immune system responses and diseases. This strain is also known for its susceptibility to developing certain types of cancer, making it useful for cancer research.

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research Alopecia Areata in Aging C3H/HeJ Mice

178 citations , June 1994 in “Journal of Investigative Dermatology”

This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.

research Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts

131 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that alopecia areata can be induced and serially transferred in C3H/HeJ mice using skin grafts, providing a useful model for studying the disease in humans.

research Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-mediated Root Sheath Disruption in Advance of Overt Hair Loss

37 citations , November 2003 in “Veterinary pathology”

This study showed that in C3H/HeJ mice, focal follicular inflammation starts before overt hair loss, with inflammation severity possibly reaching a threshold causing hair follicle dystrophy prior to visible hair loss.

research Murine Cytomegalovirus is Not Associated With Alopecia Areata in C3H/HeJ Mice

25 citations , June 1998 in “Journal of Investigative Dermatology”

Murine cytomegalovirus does not cause alopecia areata in these mice.

research Failure to induce alopecia areata in C3H/HeJ mice with exogenous interferon gamma

13 citations , December 2006 in “Journal of experimental animal science”

This study found that injecting interferon gamma into C3H/HeJ mice did not alter the frequency or onset of alopecia areata, suggesting the protein alone does not trigger the disease.

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