The Hair Loss Encyclopedia

Pathogenesis of Alopecia Areata in C3H/HeJ Mice and DEBR Rats

January 2006

Qiao Wu

alopecia areata hair follicles C3H/HeJ mice DEBR rats anagen follicles mononuclear cells cytotoxic T cells CD8+ T cells helper T cells CD4+ T cells intralesional injection triamcinolone acetonide hair regrowth autoimmune disease hair loss immune cells steroid injection steroid treatment

TLDR Alopecia areata is an autoimmune disease that targets hair follicles.

Alopecia areata, an inflammatory disease affecting hair follicles, was studied in C3H/HeJ mice and DEBR rats, which closely resemble the human condition. The disease involved histological changes in anagen follicles surrounded by mononuclear cells, primarily cytotoxic (CD8+) and helper (CD4+) T cells. Intralesional injection of triamcinolone acetonide significantly reduced this infiltration, leading to hair regrowth. The findings supported the hypothesis that alopecia areata is an autoimmune disease targeting hair follicles.

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