Altered Polyamine Profiling in the Hair of Patients with Androgenic Alopecia and Alopecia Areata

August 2019 in “ Journal of Dermatology ”

Yura Lee, Bark-Lynn Lew, Woo-Young Sim, Jeongae Lee, Jongki Hong, Bong Hyun Chung

androgenic alopecia alopecia areata polyamine profiling

Studysummary This study found that polyamine levels in hair samples differ between androgenic alopecia and alopecia areata, suggesting potential non-invasive biomarkers to distinguish between these hair loss conditions.

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The 2019 document discussed a mathematical model for the optimal design and sizing of hybrid power systems (HPSs), considering uncertainties in renewable power sources and load demands. The model used chance-constrained programming and fuzzy optimization to balance economic and environmental goals and account for uncertainties. The study found a trade-off between cost and carbon emissions, with an increase in system reliability leading to higher costs and lower emissions. The model was able to solve all system reliability levels in 0.2 CPU seconds. The study concluded that demand uncertainty should not be overlooked, especially when high system reliability is required. However, the model did not account for the efficiencies of all power electronic devices or distribution losses, suggesting areas for future research.

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research Telogen Effluvium: Causes, Diagnosis, and Treatments

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research N1-Methylspermidine, A Stable Spermidine Analog, Prolongs Anagen And Regulates Epithelial Stem Cell Functions In Human Hair Follicles

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This study found that the spermidine analog N1-methylspermidine prolonged hair follicle growth and decreased inflammation and oxidative stress in cultured hair follicles, suggesting potential relevance for treating inflammatory scalp diseases.

Ginsenoside F2 Reduces Hair Loss by Controlling Apoptosis Through the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein and Transforming Growth Factor-β Pathways in a Dihydrotestosterone-Induced Mouse Model

research Ginsenoside F2 Reduces Hair Loss by Controlling Apoptosis Through the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein and Transforming Growth Factor-β Pathways in a Dihydrotestosterone-Induced Mouse Model

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This study found that ginsenoside F2 may suppress hair cell apoptosis and improve hair growth outcomes in a DHT-induced hair loss model more effectively than finasteride.

research Commentary on: Hairless and the Polyamine Putrescine Form a Negative Regulatory Loop in the Epidermis

5 citations , October 2013 in “Experimental Dermatology”

This study observed that putrescine and HR form a negative feedback mechanism affecting hair cycling, indicating a significant connection between HR, polyamines, and hair growth regulation.

research Hairless And The Polyamine Putrescine Form A Negative Regulatory Loop In The Epidermis

10 citations , August 2013 in “Experimental Dermatology”

This study found that Hairless (HR) and putrescine form a negative regulatory network that impacts epidermal homeostasis and hair follicle cycling, linked to the MYC superfamily's regulation of ODC expression.

research Hair Steroid Profiling Reveals Racial Differences in Male Pattern Baldness Between Korean and Caucasian Populations

10 citations , November 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study reported higher dihydrotestosterone and testosterone levels in balding Korean and Caucasian subjects compared to non-balding controls, with variations suggesting racial differences in androgen metabolism.

research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions

61 citations , July 2011 in “PLOS ONE”

This study provides the first direct evidence that spermidine can stimulate hair growth and modulate human epithelial stem cell biology in cultured human hair follicles.

research Gas Chromatography/Mass Spectrometry Based Hair Steroid Profiling May Reveal Pathogenesis in Hair Follicles of the Scalp

30 citations , April 2011 in “Rapid communications in mass spectrometry/RCM. Rapid communications in mass spectrometry”

This study found that using hair steroid profiling, dutasteride treatment led to reduced dihydrotestosterone levels and DHT/testosterone ratio in patients with male-pattern baldness.

research Polyamines and Hair: A Couple in Search of Perfection

30 citations , July 2010 in “Experimental Dermatology”

This article reviews the role of polyamines in hair follicle growth and discusses potential therapeutic applications but provides no new clinical results.

Evaluation of Androgens in the Scalp Hair and Plasma of Patients with Male-Pattern Baldness Before and After Finasteride Administration

research Evaluation of Androgens in the Scalp Hair and Plasma of Patients with Male-Pattern Baldness Before and After Finasteride Administration

25 citations , January 2006 in “British Journal of Dermatology”

This study found that finasteride decreases DHT/T levels more significantly in the vertex scalp hair than in the occipital hair of patients with male pattern baldness.

research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

185 citations , August 2005 in “Autoimmunity Reviews”

This review discusses alopecia areata as a model for studying tissue-directed autoimmune diseases and reports no new clinical findings.

research Biochemical Roles of Testosterone and Epitestosterone to 5α-Reductase as Indicators of Male-Pattern Baldness

47 citations , January 2001 in “Journal of Investigative Dermatology”

High testosterone to epitestosterone ratio in hair could predict male-pattern baldness.

research Determination of Estrone and 17β-Estradiol in Human Hair by Gas Chromatography–Mass Spectrometry

64 citations , January 2000 in “The Analyst”

This study describes an efficient gas chromatography-mass spectrometry method for detecting estrone and 17 beta-estradiol concentrations in hair, finding differing levels in male and female samples.

research GC-MS Determination of Steroids Related to Androgen Biosynthesis in Human Hair with Pentafluorophenyldimethylsilyl–Trimethylsilyl Derivatisation

56 citations , January 1999 in “The Analyst”

This study used gas chromatography-mass spectrometry to simultaneously quantify androstenedione, dihydrotestosterone, dehydroepiandrosterone, testosterone, androsterone, etiocholanolone, progesterone, and pregnenolone in human hair, detecting differences in steroid concentrations between male and female samples.

research Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity

71 citations , May 1996 in “Journal of Investigative Dermatology”

This study found that overexpression of a mutated ornithine decarboxylase transgene in mice led to complete hair loss, which could be prevented or reversed with an ODC inhibitor.

research Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition

42 citations , February 1996 in “Journal of Investigative Dermatology”

This study found that spermidine, a polyamine, plays an essential role in hair growth in sheep follicles, while spermine is not required for normal follicle function.