N1-Methylspermidine, A Stable Spermidine Analog, Prolongs Anagen And Regulates Epithelial Stem Cell Functions In Human Hair Follicles

    July 2015 in “ Archives of dermatological research ”
    Yuval Ramot, Barbara Mora, Daniela Pinto, Jennifer E. Kloepper, Ralf Paus
    TLDR N1-methylspermidine helps hair growth and reduces inflammation in hair follicles.
    The study demonstrated that N1-methylspermidine (N1-MeSpd), a stable analog of spermidine, effectively prolonged the anagen phase and reduced cell apoptosis in cultured human hair follicles. At a concentration of 0.5 µM, N1-MeSpd also stimulated the expression of keratin K15, associated with epithelial stem cells, and decreased lactate dehydrogenase activity, indicating reduced cell death. Additionally, N1-MeSpd diminished reactive oxygen species production and lowered the expression of inflammatory markers such as TNF-α, IL-1β, and IL-6 in keratinocytes. These findings suggested that N1-MeSpd's effects might be due to its anti-oxidative and anti-inflammatory properties, which could be beneficial for treating inflammatory alopecias and scalp diseases.
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