N1-Methylspermidine, A Stable Spermidine Analog, Prolongs Anagen And Regulates Epithelial Stem Cell Functions In Human Hair Follicles

    July 2015 in “ Archives of dermatological research ”
    Yuval Ramot, Barbara Mora, Daniela Pinto … Ralf Paus
    Studysummary This study found that the spermidine analog N1-methylspermidine prolonged hair follicle growth and decreased inflammation and oxidative stress in cultured hair follicles, suggesting potential relevance for treating inflammatory scalp diseases.
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    Research cited in this study 11

    1. Mapping the Expression of Epithelial Hair Follicle Stem Cell-Related Transcription Factors LHX2 and SOX9 in the Human Hair Follicle Experimental Dermatology · 2015
    2. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    3. Commentary on: Hairless and the Polyamine Putrescine Form a Negative Regulatory Loop in the Epidermis Experimental Dermatology · 2013
    4. Hairless And The Polyamine Putrescine Form A Negative Regulatory Loop In The Epidermis Experimental Dermatology · 2013
    5. Endocannabinoids Limit Excessive Mast Cell Maturation And Activation In Human Skin Journal of Allergy and Clinical Immunology · 2012
    6. Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions PLOS ONE · 2011
    7. Polyamines and Hair: A Couple in Search of Perfection Experimental Dermatology · 2010
    8. Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ The FASEB Journal · 2010
    9. Cutaneous Application of Alpha-Methylspermidine Activates the Growth of Resting Hair Follicles in Mice Amino Acids · 2009
    10. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    11. Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008