Search

for
Search:

Glossary Lactate Dehydrogenase

enzyme that converts lactate to pyruvate in cells

Lactate Dehydrogenase (LDH) is an enzyme that plays a crucial role in converting sugar into energy for cells, particularly during anaerobic respiration when oxygen levels are low. Elevated levels of LDH in the blood can indicate tissue damage or disease, as it is released from cells into the bloodstream when they are damaged.

Related Terms

Research

5 / 1000+ results

research Lactate dehydrogenase activity drives hair follicle stem cell activation

202 citations , August 2017 in “Nature cell biology”

This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.

research Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

36 citations , January 2019 in “Nature communications”

This study found that Ldh activity in hair follicle stem cell-mediated squamous cell carcinoma is not necessary for tumorigenesis, as its modulation did not affect the cancer's development or characteristics.

research The effect of hypoxia on the proliferation capacity of dermal papilla cell by regulating lactate dehydrogenase

20 citations , June 2020 in “Journal of Cosmetic Dermatology”

This study found that hypoxia increases the proliferation of dermal papilla cells and highlighted the important role of lactate dehydrogenase in this process.

research Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue

10 citations , June 2018 in “Journal of visualized experiments”

This study demonstrated that lactate dehydrogenase activity is notably high in quiescent hair follicle stem cells within mouse skin using a specific enzymatic activity assay.

research Dehydrogenase, Cortisol, Dopamine, Zinc, and Vitamin D3 in Iraqi Patients with Polycystic Ovary Syndrome

February 2025 in “Iraqi Journal of Science”

This study found that women with polycystic ovary syndrome had significantly higher serum lactate dehydrogenase levels and lower levels of cortisol, dopamine, zinc, and vitamin D3 compared to healthy controls.

View more "lactate dehydrogenase" in research →

Community Join

5 / 39 results

community My summation of PP405 - looks promising

210 upvotes 1 year ago

PP405 shows promise for hair regrowth by manipulating stem cell characteristics and lactate dehydrogenase, with Phase 2a trials pending. Google Ventures' $15M investment suggests confidence, but results and market availability remain uncertain.

community PP405 Identity Research

in Research 292 upvotes 1 year ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community The Cure isn't 5 years away; it's already here.

in Research/Science 1005 upvotes 1 year ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.

community Anyone heard of scube3? And other emerging treatments?

in Research/Science 4 upvotes 1 year ago

Emerging hair loss treatments like PP405, a topical MPC inhibitor, show promise in activating stem cells for hair growth. The conversation seeks information on the development stages and accessibility of these treatments.

View more "lactate dehydrogenase" in community →