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    A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy

    Yan Shi, Jiaxuan Zhao, Hu Li … Ming Kong
    Studysummary In this study, researchers developed a drug-free microneedle patch using chitosan lactate and stem cell-derived exosomes that significantly promotes hair regeneration in animal tests compared to minoxidil, highlighting its potential as a simple and efficient hair loss treatment.
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    Research cited in this study 21

    1. Hair Grows Hair: Dual-Effective Hair Regrowth Through a Hair Enhanced Dissolvable Microneedle Patch Cooperated with Pure Yellow Light Irradiation Applied materials today · 2021
    2. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    3. Microneedles Mediated Bioinspired Lipid Nanocarriers for Targeted Treatment of Alopecia Journal of Controlled Release · 2020
    4. Follicular Unit Excision: A Hair Transplant Technique Facial Plastic Surgery Clinics of North America · 2020
    5. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    6. Hair Growth-Promoting Activities of Chitosan and Surface-Deacetylated Chitin Nanofibers International Journal of Biological Macromolecules · 2018
    7. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    8. Nature-Derived Lignan Compound VB-1 Exerts Hair Growth-Promoting Effects by Augmenting Wnt/β-Catenin Signaling in Human Dermal Papilla Cells PeerJ · 2018
    9. Androgenetic Alopecia: Drug Safety and Therapeutic Strategies Expert Opinion on Drug Safety · 2018
    10. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    11. Efficacy of Fractional Lasers in Treating Alopecia: A Literature Review Lasers in Medical Science · 2017
    12. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    13. iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration PLOS ONE · 2016
    14. Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration ACS Applied Materials & Interfaces · 2016
    15. The Autoimmune Basis of Alopecia Areata: A Comprehensive Review Autoimmunity reviews · 2014
    16. 1α,25-Dihydroxyvitamin D3 Modulates the Hair-Inductive Capacity of Dermal Papilla Cells: Therapeutic Potential for Hair Regeneration Stem Cells Translational Medicine · 2012
    17. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    18. Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells Regenerative Medicine · 2009
    19. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    20. Folliculitis Decalvans: A Rare Inflammatory Scalp Disorder Dermatologic Therapy · 2008
    21. KF19418, A New Compound for Hair Growth Promotion in Vitro and in Vivo Mouse Models Journal of Dermatological Science · 2001

    Related research 10

    1. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    2. 5% Minoxidil: Treatment for Female Pattern Hair Loss PubMed · 2015
    3. Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model Journal of Investigative Dermatology · 2010
    4. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    5. Effects of TNF-Alpha and Minoxidil on Human Hair Growth In Vitro Journal of Clinical Dermatology · 2003
    6. Effect of Minoxidil on Hair Growth in Androgenic Alopecia in Women PubMed · 2002
    7. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    8. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    9. The Use of Minoxidil to Prevent Alopecia During Chemotherapy for Gynecologic Malignancies PubMed · 1991
    10. Sulfation of Minoxidil in Keratinocytes and Hair Follicles PubMed · 1989