Hair Grows Hair: Dual-Effective Hair Regrowth Through a Hair Enhanced Dissolvable Microneedle Patch Cooperated with Pure Yellow Light Irradiation

December 2021 in “ Applied materials today ”

Can Hong, Guoliang Zhang, Wei Zhang, Jiaqi Liu, Jiao Zhang, Yutong Chen, Haichuan Peng, Yuan Cheng, Xingwei Ding, Hong‐Bo Xin, Xiaolei Wang

dissolvable microneedle patches exosomes human amniotic mesenchymal stem cells hair nanoparticles hair follicle stem cells yellow light irradiation inflammation reduction hair regrowth HMNs hAMSCs HNPs

TLDR A new microneedle patch and yellow light therapy significantly promote hair regrowth.

The study presents a novel hair regrowth technology inspired by seed germination, combining dissolvable microneedle patches (HMNs) with exosomes from human amniotic mesenchymal stem cells (hAMSCs) and hair nanoparticles (HNPs). These HMNs effectively penetrate the skin to deliver exosomes, activating hair follicle stem cells and promoting hair regrowth. Additionally, a low-color-temperature yellow light (1900 K) is used to reduce inflammation and further stimulate hair growth. Animal experiments demonstrated significant hair regrowth within 7 days, with no adverse effects, suggesting a promising clinical application for treating hair loss.

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