Priming Mobilization of Hair Follicle Stem Cells Triggers Permanent Loss of Regeneration After Alkylating Chemotherapy

    August 2019 in “ Nature Communications ”
    Jin Yong Kim, Jungyoon Ohn, Ji-Seon Yoon … Ohsang Kwon
    Studysummary In this study, researchers found that alkylating chemotherapy causes hair follicle stem cells to lose their regenerative ability by initially triggering proliferation followed by apoptosis, leading to permanent regeneration loss.
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    Research cited in this study 22

    1. Anagen Hair Follicle Repair: Timely Regenerative Attempts from Plastic Extra-Bulge Epithelial Cells Experimental Dermatology · 2019
    2. Eccrine Sweat Glands Associate With the Human Hair Follicle Within a Defined Compartment of Dermal White Adipose Tissue British Journal of Dermatology · 2018
    3. Epithelial-To-Mesenchymal Stem Cell Transition In A Human Organ: Lessons From Lichen Planopilaris Journal of Investigative Dermatology · 2017
    4. Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Cancer Research · 2017
    5. Permanent Diffuse Alopecia After Hematopoietic Stem Cell Transplantation in Childhood Bone Marrow Transplantation · 2017
    6. Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions Toward Clinical Reality ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2016
    7. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    8. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    9. Testing Chemotherapeutic Agents in the Feather Follicle Identifies a Selective Blockade of Cell Proliferation and a Key Role for Sonic Hedgehog Signaling in Chemotherapy-Induced Tissue Damage Journal of Investigative Dermatology · 2014
    10. Efficacy of Interventions for Prevention of Chemotherapy-Induced Alopecia: A Systematic Review and Meta-Analysis International journal of cancer · 2014
    11. The Human Hair: From Anatomy to Physiology International Journal of Dermatology · 2013
    12. Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle Trends in pharmacological sciences · 2013
    13. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    14. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    15. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    16. Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin Aging Cell · 2009
    17. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    18. Six Cases of Permanent Alopecia After Various Conditioning Regimens Commonly Used in Hematopoietic Stem Cell Transplantation Bone marrow transplantation · 2007
    19. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    20. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    21. Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone PubMed · 1994
    22. Effect of X-Irradiation on Differentiating Hair Follicles The anatomical record · 1960

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    1. Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model Journal of Investigative Dermatology · 2010
    2. Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae Experimental Dermatology · 2001