Six Cases of Permanent Alopecia After Various Conditioning Regimens Commonly Used in Hematopoietic Stem Cell Transplantation

September 2007 in “ Bone marrow transplantation ”

MJ Machado, Jan S. Moreb, Shahab Khan

permanent alopecia conditioning regimens hematopoietic stem cell transplantation chemotherapy busulfan cyclophosphamide hair regrowth

TLDR Certain chemotherapy drugs can cause permanent hair loss in stem cell transplant patients.

The document discussed six cases of permanent alopecia following various conditioning regimens used in hematopoietic stem cell transplantation. It highlighted that certain chemotherapy drugs, such as busulfan and cyclophosphamide, were associated with a failure of hair regrowth. The study underscored the psychological impact of alopecia on patients and the need for effective preventive measures.

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Research cited in this study

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research Protection Against Chemotherapy-Induced Alopecia

97 citations, September 2006 in “Pharmaceutical Research”

No treatment fully prevents hair loss from chemotherapy yet.

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research Atrophic Telogen Effluvium from Cytotoxic Drugs and a Randomized Controlled Trial to Investigate the Possible Protective Effect of Pretreatment with a Topical Vitamin D3 Analogue in Humans

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Topical vitamin D3 does not prevent hair loss from chemotherapy.

Topical Application of Cyclosporin A Induces Rapid Remodeling of Damaged Anagen Hair Follicles in Cyclophosphamide-Administered Mice

research Topical Application of Cyclosporin A Induces Rapid Remodeling of Damaged Anagen Hair Follicles in Cyclophosphamide-Administered Mice

24 citations, September 2001 in “Journal of Dermatological Science”

Cyclosporin A helps damaged hair follicles regrow hair quickly.

research Permanent Alopecia Following Chemotherapy and Bone Marrow Transplantation

63 citations, May 2000 in “Australasian Journal of Dermatology”

Chemotherapy and bone marrow transplant can cause permanent hair loss.

research A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia

127 citations, July 1996 in “Journal of The American Academy of Dermatology”

Minoxidil shortens baldness from chemotherapy by 50.2 days without significant side effects.

research Minoxidil as a Prophylaxis of Doxorubicin-Induced Alopecia

49 citations, October 1994 in “Annals of Oncology”

Minoxidil not effective in preventing chemotherapy-induced hair loss.

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research Permanent Chemotherapy-Induced Alopecia: Case Report and Review of the Literature

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Some chemotherapy can cause permanent hair loss.

research Permanent Diffuse Alopecia After Hematopoietic Stem Cell Transplantation in Childhood

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Some children who had stem cell transplants developed permanent hair loss, especially when treated with a drug called busulphan.

research Clinical and Histological Study of Permanent Alopecia After Bone Marrow Transplantation

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research Presentation, Impact and Prevention of Chemotherapy-Induced Hair Loss: Scalp Cooling Potentials and Limitations

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Scalp cooling can reduce chemotherapy-induced hair loss and should be available in all hospitals.

research Treatment of Chemotherapy-Induced Alopecia

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Scalp cooling can prevent chemotherapy-induced hair loss, and certain treatments can speed up hair regrowth, but more research is needed for better treatments.

Six Cases of Permanent Alopecia After Various Conditioning Regimens Commonly Used in Hematopoietic Stem Cell Transplantation

Research cited in this study

research Protection Against Chemotherapy-Induced Alopecia

research Atrophic Telogen Effluvium from Cytotoxic Drugs and a Randomized Controlled Trial to Investigate the Possible Protective Effect of Pretreatment with a Topical Vitamin D3 Analogue in Humans

research Topical Application of Cyclosporin A Induces Rapid Remodeling of Damaged Anagen Hair Follicles in Cyclophosphamide-Administered Mice

research Permanent Alopecia Following Chemotherapy and Bone Marrow Transplantation

research A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia

research Minoxidil as a Prophylaxis of Doxorubicin-Induced Alopecia

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