Sulfation of Minoxidil in Keratinocytes and Hair Follicles

October 1989 in “ PubMed ”

Tomoyuki Hamamoto, Yo Mori

minoxidil sulfation keratinocytes hair follicles fibroblasts Rogaine

TLDR Minoxidil helps hair growth by being sulfated in hair follicles.

The study investigated the sulfation of minoxidil in various skin cells, including hair follicles, keratinocytes, and fibroblasts. It found that sulfation of minoxidil occurred strongly in hair follicles and proliferative keratinocytes, while activity was extremely low in differentiating keratinocytes and fibroblasts. This strong sulfation in hair follicle cells was suggested to be related to minoxidil's hair growth-stimulating effects.

View this study on pubmed.ncbi.nlm.nih.gov →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 72 upvotes 1 year ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Comprehensive Microneedling Guide

in Microneedling 291 upvotes 3 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 6 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community Sugars ARE important for hair growth | Glycosaminoglycans as Hair Growth Stimulant

in Research/Science 77 upvotes 1 year ago

Glycosaminoglycans are important for hair growth, and combining minoxidil with tretinoin and Biopeptide-CL may enhance hair growth by boosting glycosaminoglycan levels and improving the hair follicle environment. Users discussed the potential effectiveness and future of these treatments.

community Minoxidil Sulfate makes everyone a responder

in Research/Science 260 upvotes 1 year ago

Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

Related Research

8 / 8 results

research Scalp Threading – New Treatment Option for Androgenetic Alopecia

June 2022 in “South Florida Journal of Health”

Scalp Threading is a promising new treatment for hair loss that may work better than current options.

Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil Treatment in Brazilian Female Pattern Hair Loss Patients

research Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil Treatment in Brazilian Female Pattern Hair Loss Patients

4 citations , December 2019 in “Dermatologic Therapy”

Hair enzyme activity predicts minoxidil success in Brazilian women with hair loss.

Oral Minoxidil Bio-Activation by Hair Follicle Outer Root Sheath Cell Sulfotransferase Enzymes Predicts Clinical Efficacy in Female Pattern Hair Loss

research Oral Minoxidil Bio-Activation by Hair Follicle Outer Root Sheath Cell Sulfotransferase Enzymes Predicts Clinical Efficacy in Female Pattern Hair Loss

9 citations , August 2019 in “Journal of The European Academy of Dermatology and Venereology”

Minoxidil activation by hair enzymes predicts treatment success for female hair loss.

research Androgenetic Alopecia and Its Remedies: A Review

August 2014 in “Journal of drug discovery and therapeutics”

Topical minoxidil and oral finasteride can help regrow hair in androgenetic alopecia.

research Minoxidil to Treat Androgenetic Alopecia in Men and Women: What Is It and How Does It Work?

January 2014 in “American Journal of Medicine and Medical Sciences”

Minoxidil, originally a blood pressure medication, is effective in treating hair loss in men and women, with different strengths recommended for each.

research Hair Growth-Promoting Activity of Hot Water Extract of Thuja Orientalis

54 citations , January 2013 in “BMC Complementary and Alternative Medicine”

Thuja orientalis hot water extract may help hair grow by starting the growth phase and improving hair follicle development.

research The Therapeutic Use of Topical Minoxidil

33 citations , April 1990 in “Dermatologic Clinics”

Minoxidil effectively treats hair loss, with better results in women.

research Sulfation of Minoxidil in Keratinocytes and Hair Follicles

19 citations , October 1989 in “PubMed”

Minoxidil helps hair growth by being sulfated in hair follicles.