Oral Minoxidil Bio-Activation by Hair Follicle Outer Root Sheath Cell Sulfotransferase Enzymes Predicts Clinical Efficacy in Female Pattern Hair Loss

August 2019 in “ Journal of The European Academy of Dermatology and Venereology ”

Pablo Ramos, Amir Goren, Robert Sinclair, Hélio Amante Miot

oral minoxidil hair follicle outer root sheath sulfotransferase enzymes female pattern hair loss bio-activation clinical efficacy follicular enzymatic activity topical minoxidil predictive biomarker therapeutic response OM ORS FPHL

TLDR Minoxidil activation by hair enzymes predicts treatment success for female hair loss.

The study investigated the bio-activation of oral minoxidil (OM) by hair follicle outer root sheath cell sulfotransferase enzymes and its clinical efficacy in treating female pattern hair loss (FPHL). The study found that ORS bio-activation predicts clinical response in the treatment of FPHL, and a lower follicular enzymatic activity threshold is required for bio-activation of OM compared to topical minoxidil. The study also developed a predictive biomarker for OM therapeutic response in FPHL. The results suggest that ORS sulfotransferase activity is a key factor in OM efficacy and could be used as a biomarker for predicting therapeutic response.

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