The conversation discusses how Tretinoin may improve the effectiveness of Minoxidil for treating hair loss by increasing the activity of certain enzymes in hair follicles. One user comments that this information is not new.
Low-dose daily aspirin reduces the effectiveness of topical minoxidil in treating androgenetic alopecia. Aspirin inhibits sulfotransferaseenzymes, which are necessary for minoxidil to work.
Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.
Tretinoin may enhance the effectiveness of minoxidil for hair regrowth by increasing enzyme activity and skin permeability, but its standalone impact is limited. Some users experienced improved hair growth with tretinoin, while others found it worsened their condition.
Tretinoin is used with minoxidil to enhance hair growth, with some users applying tretinoin before minoxidil to improve results. Some users report success with this combination, while others experience irritation or dryness.