Comparison of Minoxidil Sulfotransferase Activity Between Scalp Hair, Eyebrows, and Eyelashes: Implication for Minoxidil Efficacy for Off-Label Use

    April 2024 in “ Journal of cosmetic dermatology ”
    Nina Mehta, Andy Goren
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    TLDR Minoxidil is less effective on eyebrows and eyelashes than scalp hair because these areas have lower enzyme activity needed to activate the drug.
    The study investigated the activity of the enzyme SULT1A1, which activates minoxidil, a drug used for hair growth, in scalp hair, eyebrows, and eyelashes. The study involved eight patients and used the Minoxidil Response Test to assess SULT1A1 activity. The mean SULT1A1 enzyme activities in eyebrow, eyelash, and scalp hair follicles were 0.1355, 0.0392, and 0.5048, respectively. The study found that SULT1A1 activity in eyelash and eyebrow hair follicles is significantly lower than scalp hair follicles. This suggests that for minoxidil to be effective in these areas, it may be necessary to supplement eyebrow and eyelash hair follicles with sulfotransferase enzymes. However, the use of minoxidil on the face should be approached with caution due to potential side effects. The study is limited by its small sample size.
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