Hair Growth-Promoting Activities of Chitosan and Surface-Deacetylated Chitin Nanofibers

    December 2018 in “ International Journal of Biological Macromolecules ”
    Kazuo Aso, Ryo Koizumi, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Tomohiro Osaki, Norihiko Ito, Masamichi Yamashita, Takeshi Tsuka, Tomohiro Imagawa, Yoshiharu Okamoto, Tadashi Inoue, Shinsuke Ifuku
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    Studysummary This study found that chitosan and surface-deacetylated chitin nanofibrils promoted hair growth in mice and increased fibroblast growth factor-7 production in human follicle dermal papilla cells. Our plain-language summary of this paper — not a Tressless recommendation.
    The 2019 study explored the hair growth-promoting effects of chitosan and surface-deacetylated chitin nanofibers (SDACNFs) through in vitro and in vivo experiments. In vitro, both substances increased proliferation in human follicle dermal papilla cells and production of fibroblast growth factor-7 (FGF-7) by day 3. In vivo tests on mice demonstrated that chitosan and SDACNFs enhanced hair growth, with a notable rise in anagen follicles and a reduction in telogen follicles, as well as increased expression of FGF-7 and Sonic hedgehog in hair follicles. The in vivo experiments involved groups of 3-4 mice each. These findings indicate the potential of chitosan and SDACNFs as treatments for hair loss.
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