Increased Lactate Dehydrogenase Activity Is Dispensable in Squamous Carcinoma Cells of Origin

    January 2019 in “ Nature communications ”
    Aimee Flores, S. Sandoval-Gonzalez, Rie Takahashi … William E. Lowry
    Studysummary This study found that Ldh activity in hair follicle stem cell-mediated squamous cell carcinoma is not necessary for tumorigenesis, as its modulation did not affect the cancer's development or characteristics.
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    Research cited in this study 4

    1. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    2. Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors Nature Cell Biology · 2013
    3. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    4. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003