Hairless And The Polyamine Putrescine Form A Negative Regulatory Loop In The Epidermis

    August 2013 in “ Experimental Dermatology ”
    Courtney T. Luke, Alexandre Casta, Hyun-Mi Kim, Angela M. Christiano
    TLDR Hairless protein and putrescine regulate each other, affecting hair growth and skin balance.
    The study revealed a negative regulatory loop between the Hairless (HR) protein and the polyamine putrescine in the epidermis, impacting hair follicle cycling and epidermal homeostasis. HR regulated ornithine decarboxylase (ODC) expression through MYC superfamily proteins, while elevated putrescine levels decreased HR expression. This mutual regulation was linked to hair loss phenotypes in mouse models with altered HR or polyamine enzyme expression. The research suggested that putrescine influenced gene expression through various pathways, including epigenetic mechanisms, affecting a small number of genes in keratinocytes. These findings highlighted the complex regulatory mechanisms involving HR and polyamines, with implications for hair cycling and potentially carcinogenesis.
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