A Spermidine-Based Nutritional Supplement Prolongs the Anagen Phase of Hair Follicles in Humans: A Randomized, Placebo-Controlled, Double-Blind Study

    October 2017 in “ Dermatology practical & conceptual ”
    Fabio Rinaldi, Barbara Mora, Daniela Pinto, Yuval Ramot
    Studysummary This study found that a spermidine-based nutritional supplement increased the number of anagen phase hair follicles in healthy humans, suggesting potential benefits for hair loss conditions.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 21

    1. N1-Methylspermidine, A Stable Spermidine Analog, Prolongs Anagen And Regulates Epithelial Stem Cell Functions In Human Hair Follicles Archives of dermatological research · 2015
    2. Molecular Genetics of Alopecias Current problems in dermatology · 2015
    3. Commentary on: Hairless and the Polyamine Putrescine Form a Negative Regulatory Loop in the Epidermis Experimental Dermatology · 2013
    4. Hairless And The Polyamine Putrescine Form A Negative Regulatory Loop In The Epidermis Experimental Dermatology · 2013
    5. A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata British Journal of Dermatology · 2013
    6. Telogen Effluvium: A Review of Acute and Chronic Forms Indian Journal of Dermatology, Venereology and Leprology · 2013
    7. Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions PLOS ONE · 2011
    8. Marie Unna Hereditary Hypotrichosis Caused by a Novel Mutation in the Human Hairless Transcript Experimental Dermatology · 2010
    9. Polyamines and Hair: A Couple in Search of Perfection Experimental Dermatology · 2010
    10. Cutaneous Application of Alpha-Methylspermidine Activates the Growth of Resting Hair Follicles in Mice Amino Acids · 2009
    11. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    12. A Randomized Bilateral Vehicle-Controlled Study of Eflornithine Cream Combined with Laser Treatment Versus Laser Treatment Alone for Facial Hirsutism in Women Journal of the American Academy of Dermatology · 2007
    13. Randomized, Double-Blind Clinical Evaluation of the Efficacy and Safety of Topical Eflornithine HCl 13.9% Cream in the Treatment of Women with Facial Hair International Journal of Dermatology · 2006
    14. Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures Due to Spermidine/Spermine N1-Acetyltransferase Overexpression Journal of Investigative Dermatology · 2005
    15. Targeted Expression of Spermidine/Spermine N1-Acetyltransferase Increases Susceptibility to Chemically Induced Skin Carcinogenesis Carcinogenesis · 2002
    16. Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase Journal of Investigative Dermatology · 2001
    17. Ornithine Decarboxylase Transgenic Mice as a Model for Human Atrichia with Papular Lesions Experimental dermatology · 2000
    18. Overexpression of Spermidine/Spermine N1-Acetyltransferase Under the Control of Mouse Metallothionein I Promoter in Transgenic Mice: Evidence for a Striking Post-Transcriptional Regulation of Transgene Expression by a Polyamine Analogue Biochemical Journal · 1999
    19. Co-Operation Between Follicular Ornithine Decarboxylase and v-Ha-ras Induces Spontaneous Papillomas and Malignant Conversion in Transgenic Skin Carcinogenesis · 1998
    20. Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase Journal of Biological Chemistry · 1997
    21. Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity Journal of Investigative Dermatology · 1996

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    1. A Spermidine-Based Nutritional Supplement Prolongs the Anagen Phase of Hair Follicles in Humans: A Randomized, Placebo-Controlled, Double-Blind Study Dermatology practical & conceptual · 2017