Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures Due to Spermidine/Spermine N1-Acetyltransferase Overexpression

    February 2005 in “ Journal of Investigative Dermatology ”
    Marko Pietilä, Eija Pirinen, Salla Keskitalo … Juhani Jänne
    Studysummary This research suggests that defects in keratinocyte differentiation due to putrescine accumulation in SSAT transgenic mice lead to skin changes and hair loss, and reducing putrescine can promote hair regrowth.
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    Research cited in this study 5

    1. Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase Journal of Investigative Dermatology · 2001
    2. Overexpression of Spermidine/Spermine N1-Acetyltransferase Under the Control of Mouse Metallothionein I Promoter in Transgenic Mice: Evidence for a Striking Post-Transcriptional Regulation of Transgene Expression by a Polyamine Analogue Biochemical Journal · 1999
    3. Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase Journal of Biological Chemistry · 1997
    4. Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity Journal of Investigative Dermatology · 1996
    5. Ornithine Decarboxylase Expression in Cutaneous Papillomas in SENCAR Mice Is Associated with Altered Expression of Keratins 1 and 10 PubMed · 1994

    Related research 2

    1. Overexpression of Spermidine/Spermine N1-Acetyltransferase Under the Control of Mouse Metallothionein I Promoter in Transgenic Mice: Evidence for a Striking Post-Transcriptional Regulation of Transgene Expression by a Polyamine Analogue Biochemical Journal · 1999
    2. Overexpression of Spermidine/Spermine N1-Acetyltransferase Under the Control of Mouse Metallothionein I Promoter in Transgenic Mice: Evidence for a Striking Post-Transcriptional Regulation of Transgene Expression by a Polyamine Analogue Biochemical Journal · 1999