Overexpression of Spermidine/Spermine N1-Acetyltransferase Under the Control of Mouse Metallothionein I Promoter in Transgenic Mice: Evidence for a Striking Post-Transcriptional Regulation of Transgene Expression by a Polyamine Analogue

    March 1999 in “ Biochemical Journal ”
    Suvikki Suppola, Marko Pietilä, Jyrki Parkkinen … Juhani Jänne
    Studysummary In this study, transgenic mice overexpressing the SSAT gene were highly sensitive to polyamine analogues, leading to severe liver changes and high mortality rates after treatment.
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