Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

July 2004 in “ Journal of Biological Chemistry ”

Kristin Kee, Barbara A. Foster, Salim Merali, Debora L. Kramer, Mary L. Hensen, Paula Diegelman, Nicholas Kisiel, Slavoljub Vujcic, Richard Mazurchuk, Carl W. Porter

spermidine spermine N1-acetyltransferase SSAT acetyl-CoA S-adenosylmethionine polyamine catabolism TRAMP mice prostate cancer

Studysummary This study found that overexpression of the enzyme SSAT in a mouse model significantly reduced prostate tumor size and progression, suggesting it could be a promising strategy against prostate cancer.

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research Targeted Expression of Spermidine/Spermine N1-Acetyltransferase Increases Susceptibility to Chemically Induced Skin Carcinogenesis

54 citations , February 2002 in “Carcinogenesis”

This study suggests that activation of polyamine catabolism in K6-SSAT transgenic mice may significantly increase skin tumor development and progression to carcinomas following chemical induction.

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

54 citations , May 2001 in “Journal of Investigative Dermatology”

This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.

research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

124 citations , July 1997 in “Journal of Biological Chemistry”

This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.