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research Cell fate decisions: emerging roles for metabolic signals and cell morphology

100 citations , November 2017 in “EMBO Reports”

This review discusses the roles of metabolism, reactive oxygen species, intracellular pH, and cell morphology in influencing cell fate decisions during stem cell differentiation but reports no new experimental results.

research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

91 citations , July 2004 in “Journal of Biological Chemistry”

This study found that overexpression of the enzyme SSAT in a mouse model significantly reduced prostate tumor size and progression, suggesting it could be a promising strategy against prostate cancer.

research Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition

42 citations , February 1996 in “Journal of Investigative Dermatology”

This study found that spermidine, a polyamine, plays an essential role in hair growth in sheep follicles, while spermine is not required for normal follicle function.

research Vitamin B12 Malabsorption: The Pathophysiological Impacts on Neurological and Hair Physiology

January 2025 in “The International Journal of Gastroenterology and Hepatology Diseases”

This study explored how vitamin B12 is essential for hair growth and nervous system health, highlighting that factors causing its malabsorption, like gastric issues and smoking, can lead to optic neuropathy and hair loss.

research Investigation of Some Amino Acid Analogues and Metabolites as Inhibitors of Wool and Hair Growth

5 citations , May 1983 in “Australian journal of biological sciences”

This study found that concurrent administration of cycloleucine with ethionine prevented the weakening of wool fibers in sheep, whereas reduced glutathione did not have the same effect.

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Learn

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learn acetyl methionine

learn L-methionine

learn methylsulfonylmethane

learn acetyl cysteine

learn Botox

What’s the science behind Botox injections for androgenetic alopecia? Small published studies and a 2025 meta-analysis report hair-count gains from scalp botulinum toxin injections, but nearly all of them lack control groups, and reviewers of the same literature call the evidence low-quality; the treatment is off-label and not approved for hair loss anywhere.

learn Glycerin

What’s the difference between vegetable glycerin and synthetic glycerin in hair products? Vegetable glycerin is plant-derived, while synthetic glycerin is petroleum-based, but both are chemically identical.

Community Join

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community What's the point of finasteride if dutasteride exists?

43 upvotes 3 days ago

Finasteride is effective for hair loss with fewer side effects and quicker clearance compared to dutasteride, which is more potent but has a longer half-life and potentially more side effects. Users suggest starting with finasteride and considering dutasteride only if more hair retention is needed and side effects are manageable.

community What's the proper way to use a derma stamp?

104 upvotes 1 week ago

A user is seeking advice on using a derma stamp for hair loss treatment, alongside minoxidil and finasteride. Recommendations include cleaning the scalp, using alcohol or hypochlorous acid for sterilization, starting with a needle length of 0.5mm, and stamping once a week.

community What's your unpopular opinion?

56 upvotes 2 weeks ago

Minoxidil is criticized for being inconvenient and ineffective compared to finasteride, with some users experiencing issues like flaking and greasy hair. Alternatives like adenosine are suggested, and the effectiveness of minoxidil can be improved with tretinoin and dietary changes.

community Let’s be real, does infrequent smoking really accelerate MPB and/or cause health issues?

10 upvotes 2 weeks ago

Smoking infrequently is unlikely to significantly impact hair loss or health, especially when using treatments like finasteride and minoxidil. Genetics play a larger role in hair loss, and low smoking frequency is not considered a major risk.

community How’s my progress? 2 months in - 2.5 mg min, 1 mg fin

21 upvotes 3 weeks ago

The user resumed 2.5 mg oral minoxidil and added 1 mg finasteride, Nizoral 2%, Vitamin D3+K2, and Biotin after noticing hair loss. They are seeing progress and are encouraged by the results after two months.

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