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GlossarySpermine

naturally occurring compound involved in cellular metabolism and DNA stabilization

Spermine is a naturally occurring polyamine compound found in all eukaryotic cells. It plays a crucial role in cellular metabolism and is involved in stabilizing the structure of DNA, RNA, and various proteins. In the context of hair and alopecia, spermine has been studied for its potential effects on hair growth and follicle health.

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research Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition

42 citations , February 1996 in “Journal of Investigative Dermatology”

Polyamines, especially spermidine, are essential for hair growth.

Synthetic Studies Toward the Development of Novel Minoxidil Analogs and Conjugates with Polyamines

research Synthetic Studies Toward the Development of Novel Minoxidil Analogs and Conjugates with Polyamines

12 citations , February 2010 in “Tetrahedron Letters”

New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.

research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

124 citations , July 1997 in “Journal of Biological Chemistry”

Overexpressing a specific enzyme in mice causes hair loss and female infertility.

Increased Hair Polyamine Levels in Patients with Alzheimer's Disease

research Increased Hair Polyamine Levels in Patients with Alzheimer's Disease

10 citations , June 2001 in “Annals of neurology”

Alzheimer's patients have higher levels of certain chemicals in their hair.

research Spermidine/Spermine-N1-Acetyltransferase: A Key Metabolic Regulator

305 citations , March 2008 in “AJP Endocrinology and Metabolism”

SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.

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