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GlossarySpermine

naturally occurring compound involved in cellular metabolism and DNA stabilization

Spermine is a naturally occurring polyamine compound found in all eukaryotic cells. It plays a crucial role in cellular metabolism and is involved in stabilizing the structure of DNA, RNA, and various proteins. In the context of hair and alopecia, spermine has been studied for its potential effects on hair growth and follicle health.

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research Overexpression of Spermidine/Spermine N1-Acetyltransferase Under the Control of Mouse Metallothionein I Promoter in Transgenic Mice: Evidence for a Striking Post-Transcriptional Regulation of Transgene Expression by a Polyamine Analogue

43 citations, February 1999 in “Biochemical Journal”

Overexpression of SSAT in mice causes hair loss, liver damage, and sensitivity to polyamine analogues.

research Polyamines and Hair: A Couple in Search of Perfection

30 citations, July 2010 in “Experimental Dermatology”

Polyamines are important for hair growth, but more research is needed to understand their functions and treatment potential.

research Topical Spermine And Putrescine Stimulated DNA Synthesis In The Hairless Mouse Epidermis

10 citations, July 1980 in “British Journal of Dermatology”

Topical putrescine and spermine increased DNA synthesis in hairless mouse skin.

research Synthetic Studies Toward the Development of Novel Minoxidil Analogs and Conjugates with Polyamines

12 citations, February 2010 in “Tetrahedron Letters”

New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.

research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

124 citations, July 1997 in “Journal of Biological Chemistry”

Overexpressing a specific enzyme in mice causes hair loss and female infertility.

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